Visible-Light-Induced Domino Perfluoroalkylation/Cyclization to Access Perfluoroalkylated Quinazolinones by an EDA Complex

被引：13

作者：

Meng, Fei ^{[1
]}

Cui, Yangyang ^{[1
]}

Xu, Wen ^{[1
]}

Yang, Wen-Chao ^{[1
]}

机构：

[1] Yangzhou Univ, Inst Pesticide, Coll Plant Protect, Yangzhou 225009, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 32期

关键词：

N-CYANAMIDE ALKENES; PHOTOREDOX CATALYSIS; RECENT PROGRESS; TRIFLUOROMETHYLATION; FLUORINE; PHARMACEUTICALS; DERIVATIVES; CYCLIZATION; CHEMISTRY; ANALOGS;

D O I：

10.1021/acs.orglett.4c02465

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The electron donor-acceptor (EDA) complexes have been extensively studied, which formed an electronically excited state, obviating the need for an exogenous photocatalyst. Herein, we report a mild and efficient strategy for photoinduced radical domino perfluoroalkylation/cyclization using N,N,N ',N '-tetramethylethane-1,2-diamine (TMEDA) as an electron donor. This protocol could be well expanded to access various polycyclic quinazolinones containing perfluoroalkyl groups, exhibiting photocatalyst-free, good functional group tolerance, and environmentally friendly features.

引用

页码：6884 / 6888

页数：5

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