Bone marrow necrosis and fat embolism syndrome in sickle cell disease during COVID-19 infection treated successfully with sequential red cell and plasma exchange

被引:5
|
作者
Rizvi, Syed [1 ,9 ]
Khakwani, Muhammad [2 ]
Pancham, Shivan [3 ]
Tsitsikas, Dimitris [4 ]
Rudzki, Zbigniew [5 ]
Hassan-Smith, Ghaniah [6 ]
Bowen, Michael [7 ]
Wright, Christine [3 ]
Park, Daniel [8 ]
机构
[1] Univ Hosp Birmingham UHB NHS Fdn Trust, Dept Acute Internal Med, Birmingham, England
[2] Univ Hosp Birmingham UHB NHS Fdn Trust, Dept Haematol, Birmingham, England
[3] Sandwell & West Birmingham Hosp SWBH NHS Trust, Dept Haematol, Birmingham, England
[4] Homerton Univ Hosp HUH NHS Fdn Trust, Dept Haematol, London, England
[5] Univ Hosp Birmingham UHB NHS Fdn Trust, Dept Histopathol, Birmingham, England
[6] Univ Hosp Birmingham UHB NHS Fdn Trust, Dept Neurol, Birmingham, England
[7] Univ Hosp Birmingham UHB NHS Fdn Trust, Dept Neuroradiol, Birmingham, England
[8] Univ Hosp Birmingham UHB NHS Fdn Trust, Dept Resp & Crit Care Med, Birmingham, England
[9] Sandwell & West Birmingham Hosp NHS Trust, Birmingham City Hosp, Dept Acute Internal Med, Dudley Rd, Birmingham B18 7QH, England
来源
EJHAEM | 2023年 / 4卷 / 01期
关键词
bone marrow necrosis; COVID19; fat embolism syndrome; neurological impairment; plasma exchange; sickle cell disease;
D O I
10.1002/jha2.621
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Fat embolism syndrome (FES) is a rare life-threatening condition that is particularly seen in milder forms of sickle cell disease (SCD). Widespread systemic fat emboli are generated in the context of extensive bone marrow necrosis. Multi-organ failure with a high morbidity and mortality may quickly develop. Infection with Parvovirus B19 is a common precipitant.Here, the authors report the case of a 35-year-old Afro-Caribbean man with HbSC disease who presented with FES having tested positive for SARS-COV-2. He rapidly became critically ill and required admission to the intensive care unit for organ support. He was treated with red cell exchange and plasma exchange and made a good recovery to leave hospital at week 7.
引用
收藏
页码:207 / 210
页数:4
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