Gold-Catalyzed C-N Cross-Coupling Reactions of Aryl Iodides with Alkyl Nitriles or Silver Cyanate

被引：5

作者：

Liu, Hongyan ^{[1
]}

Xu, Bo ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem & Chem Engn, Key Lab Sci & Technol Ecotext, Minist Educ, Shanghai 201620, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 26期

基金：

美国国家科学基金会;

关键词：

ALPHA-ARYLATION; REACTIVITY; COMPLEXES; HALIDES; DESIGN;

D O I：

10.1021/acs.orglett.4c01538

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have gold-catalyzed C-N cross-couplings of aryl iodides with aliphatic nitriles. Although nitriles are usually challenging nitrogen cross-coupling partners, they could be activated by base-mediated deprotonation and isomerization. The method utilizes widely available substrates in moderate to good yields to provide various N-aryl compounds. In addition, a similar strategy could be extended to the cross-couplings of aryl iodides with silver cyanate. The protocol features high humidity/air tolerance and works inter- and intramolecularly.

引用

收藏

页码：5430 / 5435

页数：6

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