Exploring causal mechanisms of psychosis risk

被引：5

作者：

Oliver, Dominic ^{[1
,2
,3
,4
,17
]}

Chesney, Edward ^{[5
,6
]}

Cullen, Alexis E. ^{[5
,7
]}

Davies, Cathy ^{[5
,8
]}

Englund, Amir ^{[6
]}

Gifford, George ^{[1
]}

Kerins, Sarah ^{[4
,5
]}

Lalousis, Paris Alexandros ^{[5
,9
]}

Logeswaran, Yanakan ^{[4
,10
]}

Merritt, Kate ^{[11
]}

Zahid, Uzma ^{[12
]}

Crossley, Nicolas A. ^{[1
,13
]}

McCutcheon, Robert A. ^{[1
,5
,14
]}

McGuire, Philip ^{[1
,2
,3
]}

Fusar-Poli, Paolo ^{[4
,9
,15
,16
]}

机构：

[1] Univ Oxford, Dept Psychiat, Oxford, England

[2] NIHR Oxford Hlth Biomed Res Ctr, Oxford, England

[3] Oxford Hlth NHS Fdn Trust, OPEN Early Detect Serv, Oxford, England

[4] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England

[5] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England

[6] Kings Coll London, Inst Psychiat Psychol & Neurosci, Addict Dept, 4 Windsor Walk, London SE5 8AF, England

[7] Karolinska Inst, Dept Clin Neurosci, Solna, Sweden

[8] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, London, England

[9] Ludwig Maximilian Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany

[10] Kings Coll London, Dept Biostat & Hlth Informat, London, England

[11] UCL, Inst Mental Hlth, Div Psychiat, London, England

[12] Kings Coll London, Dept Psychol, London, England

[13] Pontificia Univ Catolica Chile, Sch Med, Dept Psychiat, Santiago, Chile

[14] Oxford Hlth NHS Fdn Trust, Oxford, England

[15] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy

[16] South London & Maudsley NHS Fdn Trust, OASIS Serv, London SE11 5DL, England

[17] Univ Oxford, POWIC Bldg,Warneford Lane, Oxford OX4 1PD, England

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2024年 / 162卷

基金：

英国惠康基金;

关键词：

Psychosis; Prevention; Risk factors; Neurobiology; Neurodevelopment; Dopamine; Glutamate; PITUITARY-ADRENAL AXIS; CLINICAL HIGH-RISK; ULTRA-HIGH RISK; STRIATAL DOPAMINE RELEASE; 1ST EPISODE PSYCHOSIS; TREATMENT-RESISTANT SCHIZOPHRENIA; NEURODEVELOPMENTAL ANIMAL-MODEL; POSITRON-EMISSION-TOMOGRAPHY; CORTISOL AWAKENING RESPONSE; PRENATAL IMMUNE ACTIVATION;

D O I：

10.1016/j.neubiorev.2024.105699

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Robust epidemiological evidence of risk and protective factors for psychosis is essential to inform preventive interventions. Previous evidence syntheses have classified these risk and protective factors according to their strength of association with psychosis. In this critical review we appraise the distinct and overlapping mechanisms of 25 key environmental risk factors for psychosis, and link these to mechanistic pathways that may contribute to neurochemical alterations hypothesised to underlie psychotic symptoms. We then discuss the implications of our findings for future research, specifically considering interactions between factors, exploring universal and subgroup-specific factors, improving understanding of temporality and risk dynamics, standardising operationalisation and measurement of risk and protective factors, and developing preventive interventions targeting risk and protective factors.

引用

页数：26

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