One-pot formal [3+2] annulation of 2-pyridinyl-substituted p-quinone methides and arynes for the synthesis of 3-aryl pyrido[1,2-a]indoles

被引：1

作者：

Li, Mengfan ^{[1
]}

Chen, Yan ^{[1
]}

Tang, Hao ^{[1
]}

Cheng, Wen ^{[1
]}

Liao, Benren ^{[2
]}

Wang, Qingwei ^{[3
]}

Yi, Weiyin ^{[1
]}

机构：

[1] Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China

[2] Shanghai 4 Reagent Chem Co Ltd, Shanghai 201512, Peoples R China

[3] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 27期

关键词：

DERIVATIVES; CYCLIZATION;

D O I：

10.1039/d4ob00684d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and metal-free method for the synthesis of 3-aryl pyrido[1,2-a]indoles from aryne intermediates and 2-pyridinyl-substituted p-QMs was successfully developed under ambient conditions. The reaction offered a novel and practical protocol to access some diverse functional molecules in good to excellent yields. The proposed mechanism indicated that the reaction proceeded via a formal [3 + 2] cycloaddition step.

引用

页码：5618 / 5628

页数：11

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