Successful combination treatment with azacitidine and venetoclax as a bridging therapy for third allogenic stem cell transplantation in a patient with 11q23/MLL-rearranged complex karyotype acute myeloid leukemia

被引：2

作者：

Edahiro, Taro ^{[1
]}

Ureshino, Hiroshi ^{[1
,2
]}

Chishaki, Ren ^{[1
]}

Fujino, Keita ^{[1
]}

Mino, Tatsuji ^{[1
]}

Yoshida, Tetsumi ^{[1
]}

Fukushima, Noriyasu ^{[3
]}

Ichinohe, Tatsuo ^{[1
,2
]}

机构：

[1] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Hematol & Oncol, 1-2-3 Kasumi,Minami Ku, Hiroshima 7348553, Japan

[2] Hiroshima Univ, Res Inst Radiat Biol & Med RIRBM, Next Generat Dev Genome & Cellular Therapy Program, Hiroshima, Japan

[3] Karatsu Red Cross Hosp, Dept Internal Med, Karatsu, Japan

来源：

EJHAEM | 2023年 / 4卷 / 01期

关键词：

11q23/MLL-rearranged acute myeloid leukemia; azacitidine; BCL-2; venetoclax;

D O I：

10.1002/jha2.630

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Translocation t(6;11) occurs in approximately 5% of patients with acute myeloid leukemia (AML) corresponding to 11q23/mixed lineage leukemia (MLL) rearrangement. The AF6 gene on chromosome 6q27 is the fusion partner of the MLL gene on 11q23 in t(6;11), which results in a poor prognosis. The case of a patient with 11q23/MLL-rearranged AML who successfully underwent a third allogeneic stem cell transplantation after treatment with azacitidine (AZA) and venetoclax (VEN) is presented in this article. This report suggests that a combination of AZA and VEN is an effective therapeutic approach for relapsed and refractory MLL-rearranged AML.

引用

页码：273 / 275

页数：3

共 8 条

[1] Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study [J].

Balgobind, Brian V. ;

Raimondi, Susana C. ;

Harbott, Jochen ;

Zimmermann, Martin ;

Alonzo, Todd A. ;

Auvrignon, Anne ;

Beverloo, H. Berna ;

Chang, Myron ;

Creutzig, Ursula ;

Dworzak, Michael N. ;

Forestier, Erik ;

Gibson, Brenda ;

Hasle, Henrik ;

Harrison, Christine J. ;

Heerema, Nyla A. ;

Kaspers, Gertjan J. L. ;

Leszl, Anna ;

Litvinko, Nathalia ;

Lo Nigro, Luca ;

Morimoto, Akira ;

Perot, Christine ;

Pieters, Rob ;

Reinhardt, Dirk ;

Rubnitz, Jeffrey E. ;

Smith, Franklin O. ;

Stary, Jan ;

Stasevich, Irina ;

Strehl, Sabine ;

Taga, Takashi ;

Tomizawa, Daisuke ;

Webb, David ;

Zemanova, Zuzana ;

Zwaan, C. Michel ;

van den Heuvel-Eibrink, Marry M. .

BLOOD, 2009, 114 (12) :2489-2496

[2] MLL-Rearranged Acute Lymphoblastic Leukemias Activate BCL-2 through H3K79 Methylation and Are Sensitive to the BCL-2-Specific Antagonist ABT-199 [J].

Benito, Juliana M. ;

Godfrey, Laura ;

Kojima, Kensuke ;

Hogdal, Leah ;

Wunderlich, Mark ;

Geng, Huimin ;

Marzo, Isabel ;

Harutyunyan, Karine G. ;

Golfman, Leonard ;

North, Phillip ;

Kerry, Jon ;

Ballabio, Erica ;

Ni Chonghaile, Triona ;

Gonzalo, Oscar ;

Qiu, Yihua ;

Jeremias, Irmela ;

Debose, LaKiesha ;

O'Brien, Eric ;

Ma, Helen ;

Zhou, Ping ;

Jacamo, Rodrigo ;

Park, Eugene ;

Coombes, Kevin R. ;

Zhang, Nianxiang ;

Thomas, Deborah A. ;

O'Brien, Susan ;

Kantarjian, Hagop M. ;

Leverson, Joel D. ;

Kornblau, Steven M. ;

Andreeff, Michael ;

Mueschen, Markus ;

Zweidler-McKay, Patrick A. ;

Mulloy, James C. ;

Letai, Anthony ;

Milne, Thomas A. ;

Konopleva, Marina .

CELL REPORTS, 2015, 13 (12) :2715-2727

[3] Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia [J].

DiNardo, C. D. ;

Jonas, B. A. ;

Pullarkat, V. ;

Thirman, M. J. ;

Garcia, J. S. ;

Wei, A. H. ;

Konopleva, M. ;

Doehner, H. ;

Letai, A. ;

Fenaux, P. ;

Koller, E. ;

Havelange, V. ;

Leber, B. ;

Esteve, J. ;

Wang, J. ;

Pejsa, V. ;

Hajek, R. ;

Porkka, K. ;

Illes, A. ;

Lavie, D. ;

Lemoli, R. M. ;

Yamamoto, K. ;

Yoon, S. -S. ;

Jang, J. -H. ;

Yeh, S. -P. ;

Turgut, M. ;

Hong, W. -J. ;

Zhou, Y. ;

Potluri, J. ;

Pratz, K. W. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (07) :617-629

[4] Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia [J].

DiNardo, Courtney D. ;

Pratz, Keith ;

Pullarkat, Vinod ;

Jonas, Brian A. ;

Arellano, Martha ;

Becker, Pamela S. ;

Frankfurt, Olga ;

Konopleva, Marina ;

Wei, Andrew H. ;

Kantarjian, Hagop M. ;

Xu, Tu ;

Hong, Wan-Jen ;

Chyla, Brenda ;

Potluri, Jalaja ;

Pollyea, Daniel A. ;

Letai, Anthony .

BLOOD, 2019, 133 (01) :7-17

[5] Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel [J].

Doehner, Hartmut ;

Estey, Elihu ;

Grimwade, David ;

Amadori, Sergio ;

Appelbaum, Frederick R. ;

Buechner, Thomas ;

Dombret, Herve ;

Ebert, Benjamin L. ;

Fenaux, Pierre ;

Larson, Richard A. ;

Levine, Ross L. ;

Lo-Coco, Francesco ;

Naoe, Tomoki ;

Niederwieser, Dietger ;

Ossenkoppele, Gert J. ;

Sanz, Miguel ;

Sierra, Jorge ;

Tallman, Martin S. ;

Tien, Hwei-Fang ;

Wei, Andrew H. ;

Lowenberg, Bob ;

Bloomfield, Clara D. .

BLOOD, 2017, 129 (04) :424-447

[6] Venetoclax responses of pediatric ALL xenografts reveal sensitivity of MLL-rearranged leukemia [J].

Khaw, Seong Lin ;

Suryani, Santi ;

Evans, Kathryn ;

Richmond, Jennifer ;

Robbins, Alissa ;

Kurmasheva, Raushan T. ;

Billups, Catherine A. ;

Erickson, Stephen W. ;

Guo, Yuelong ;

Houghton, Peter J. ;

Smith, Malcolm A. ;

Carol, Hernan ;

Roberts, Andrew W. ;

Huang, David C. S. ;

Lock, Richard B. .

BLOOD, 2016, 128 (10) :1382-1395

[7] Daratumumab and venetoclax in combination with chemotherapy provide sustained molecular remission in relapsed/refractory CD19, CD20, and CD22 negative acute B lymphoblastic leukemia with KMT2A-AFF1 transcript [J].

Voruz, Sophie ;

Blum, Sabine ;

de Leval, Laurence ;

Schoumans, Jacqueline ;

Solly, Francoise ;

Spertini, Olivier .

BIOMARKER RESEARCH, 2021, 9 (01)

[8] Relapse of acute myeloid leukemia after allogeneic hematopoietic cell transplantation: clinical features and outcomes [J].

Yanada, Masamitsu ;

Konuma, Takaaki ;

Yamasaki, Satoshi ;

Kondo, Tadakazu ;

Fukuda, Takahiro ;

Shingai, Naoki ;

Sawa, Masashi ;

Ozawa, Yukiyasu ;

Tanaka, Masatsugu ;

Uchida, Naoyuki ;

Nakamae, Hirohisa ;

Katayama, Yuta ;

Matsuoka, Ken-ichi ;

Kimura, Takafumi ;

Kanda, Yoshinobu ;

Ichinohe, Tatsuo ;

Atsuta, Yoshiko ;

Yano, Shingo .

BONE MARROW TRANSPLANTATION, 2021, 56 (05) :1126-1133

← 1 →