Is stimulation of browning of human adipose tissue a relevant therapeutic target?

被引：1

作者：

Carpentier, Andre C. ^{[1
]}

Blondin, Denis P. ^{[2
]}

机构：

[1] Univ Sherbrooke, Ctr Rech Ctr Hosp Univ Sherbrooke, Dept Med, Div Endocrinol, Sherbrooke, PQ, Canada

[2] Univ Sherbrooke, Ctr Rech Ctr Hosp Univ Sherbrooke, Dept Med, Div Neurol, Sherbrooke, PQ, Canada

来源：

ANNALES D ENDOCRINOLOGIE | 2024年 / 85卷 / 03期

关键词：

Brown adipose tissue; White adipose tissue; Energy metabolism; Fatty acid metabolism; Glucose metabolism; Positron emission tomography; Obesity; Insulin resistance; Diabetes; COLD-INDUCED THERMOGENESIS; DIET-INDUCED THERMOGENESIS; ENERGY-EXPENDITURE; FATTY-ACID; OXIDATIVE-METABOLISM; OUTDOOR TEMPERATURE; INSULIN SENSITIVITY; SKELETAL-MUSCLES; GLUCOSE-UPTAKE; BLOOD-FLOW;

D O I：

10.1016/j.ando.2024.05.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brown adipose tissue (BAT) and beige adipose tissues are important contributors to cold -induced whole body thermogenesis in rodents. The documentation in humans of cold- and ss-adrenergic receptor agonist-stimulated BAT glucose uptake using positron emission tomography (PET) and of a decrease of this response in individuals with cardiometabolic disorders led to the suggestion that BAT/beige adipose tissues could be relevant targets for prevention and treatment of these conditions. In this brief review, we will critically assess this question by first describing the basic rationale for this affirmation, second by examining the evidence in human studies, and third by discussing the possible means to activate the thermogenic response of these tissues in humans. (c) 2024 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY -NC license (http://creativecommons.org/licenses/by-nc/4.0/).

引用

页码：184 / 189

页数：6

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