MicroRNA-124a promoted the differentiation of bone marrow mesenchymal stem cells into neurons through Notch signal pathway

被引：0
|
作者：
Wang, Daimei [1 ]
Jing, Lijun [2 ]
Zhao, Zhongyan [1 ]
Huang, Shixiong [1 ]
Xie, Ling [1 ]
Hu, Shijun [1 ]
Liang, Hui [1 ]
Chen, Yanquan [1 ]
Zhao, Eryi [1 ]
机构：
[1] Hainan Med Univ, Hainan Gen Hosp, Hainan Affiliated Hosp, Dept Neurol, 19 Xiuhua Rd, Haikou 570311, Hainan, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2024年 / 29卷 / 01期
关键词：
MicroRNA-124a; BMSCs; Notch; Hes1;
D O I：
10.1186/s40001-024-02061-6
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
This study investigated the possible mechanisms of microRNA-124a on the differentiation of bone marrow mesenchymal stem cells (BMSCs) and its underlying mechanism. beta-Thiol ethanol induced Notch1 mRNA expression, microRNA-124a inhibitor reduced the effects of beta-thiol ethanol on Notch1 mRNA expression in BMSCs. Baicalin induced Hes1 mRNA expression, and microRNA-124a inhibitor reduced the effects of baicalin on Hes1 mRNA expression in BMSCs. Si-Notch1 suppressed Hes1 mRNA expression in BMSCs. Baicalin increased the effects of Notch1 on Hes1 mRNA expression in BMSCs. Si-Notch1 increased cell growth of BMSCs. Baicalin reduced the effects of si-Notch1 on cell growth and the differentiation of BMSCs. We demonstrated that microRNA-124a promoted the differentiation of BMSCs into neurons through Notch/Hes1 signal pathway.
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页数：9
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