MicroRNA-124a promoted the differentiation of bone marrow mesenchymal stem cells into neurons through Notch signal pathway

被引：0

作者：

Wang, Daimei ^{[1
]}

Jing, Lijun ^{[2
]}

Zhao, Zhongyan ^{[1
]}

Huang, Shixiong ^{[1
]}

Xie, Ling ^{[1
]}

Hu, Shijun ^{[1
]}

Liang, Hui ^{[1
]}

Chen, Yanquan ^{[1
]}

Zhao, Eryi ^{[1
]}

机构：

[1] Hainan Med Univ, Hainan Gen Hosp, Hainan Affiliated Hosp, Dept Neurol, 19 Xiuhua Rd, Haikou 570311, Hainan, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2024年 / 29卷 / 01期

关键词：

MicroRNA-124a; BMSCs; Notch; Hes1;

D O I：

10.1186/s40001-024-02061-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study investigated the possible mechanisms of microRNA-124a on the differentiation of bone marrow mesenchymal stem cells (BMSCs) and its underlying mechanism. beta-Thiol ethanol induced Notch1 mRNA expression, microRNA-124a inhibitor reduced the effects of beta-thiol ethanol on Notch1 mRNA expression in BMSCs. Baicalin induced Hes1 mRNA expression, and microRNA-124a inhibitor reduced the effects of baicalin on Hes1 mRNA expression in BMSCs. Si-Notch1 suppressed Hes1 mRNA expression in BMSCs. Baicalin increased the effects of Notch1 on Hes1 mRNA expression in BMSCs. Si-Notch1 increased cell growth of BMSCs. Baicalin reduced the effects of si-Notch1 on cell growth and the differentiation of BMSCs. We demonstrated that microRNA-124a promoted the differentiation of BMSCs into neurons through Notch/Hes1 signal pathway.

引用

页数：9

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