Insecticide-Treated Nets and Protection against Insecticide-Resistant Malaria Vectors in Western Kenya

被引：35

作者：

Ochomo, Eric ^{[1
]}

Chahilu, Mercy ^{[1
]}

Cook, Jackie ^{[2
]}

Kinyari, Teresa ^{[3
]}

Bayoh, Nabie M. ^{[4
]}

West, Philippa ^{[2
]}

Kamau, Luna ^{[5
]}

Osangale, Aggrey ^{[1
]}

Ombok, Maurice ^{[1
]}

Njagi, Kiambo ^{[6
]}

Mathenge, Evan ^{[5
]}

Muthami, Lawrence ^{[5
]}

Subramaniam, Krishanthi ^{[7
]}

Knox, Tessa ^{[8
]}

Mnavaza, Abraham ^{[8
]}

Donnelly, Martin James ^{[7
]}

Kleinschmidt, Immo ^{[2
,9
]}

Mbogo, Charles ^{[10
,11
]}

机构：

[1] Kenya Med Res Inst KEMRI, Kisumu, Kenya

[2] London Sch Hyg & Trop Med, London, England

[3] Univ Nairobi, Nairobi, Kenya

[4] US Ctr Dis Control & Prevent Kenya, Nairobi, Kenya

[5] KEMRI, Nairobi, Kenya

[6] Minist Hlth, Nairobi, Kenya

[7] Univ Liverpool Liverpool Sch Trop Med, Liverpool, Merseyside, England

[8] World Hlth Org, Geneva, Switzerland

[9] Univ Witwatersrand, Johannesburg, South Africa

[10] KEMRI, Kilifi, Kenya

[11] KEMRI Wellcome Trust, Nairobi, Kenya

来源：

EMERGING INFECTIOUS DISEASES | 2017年 / 23卷 / 05期

关键词：

PLASMODIUM-FALCIPARUM; PYRETHROID RESISTANCE; ANOPHELES-FUNESTUS; BED NETS; MOSQUITOS; EFFICACY; IMPACT; AREA; AFRICA; COHORT;

D O I：

10.3201/eid2305.161315

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Insecticide resistance might reduce the efficacy of malaria vector control. In 2013 and 2014, malaria vectors from 50 villages, of varying pyrethroid resistance, in western Kenya were assayed for resistance to deltamethrin. Long-lasting insecticide-treated nets (LLIN) were distributed to house-holds at universal coverage. Children were recruited into 2 cohorts, cleared of malaria-causing parasites, and tested every 2 weeks for reinfection. Infection incidence rates for the 2 cohorts were 2.2 (95% CI 1.9-2.5) infections/person-year and 2.8 (95% CI 2.5-3.0) infections/person-year. LLIN users had lower infection rates than non-LLIN users in both low-resistance (rate ratio 0.61, 95% CI 0.42-0.88) and high-resistance (rate ratio 0.55, 95% CI 0.35-0.87) villages (p = 0.63). The association between insecticide resistance and infection incidence was not significant (p = 0.99). Although the incidence of infection was high among net users, LLINs provided significant protection (p = 0.01) against infection with malaria parasite regardless of vector insecticide resistance.

引用

页码：758 / 764

页数：7

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