Differential effects of deep brain stimulation on reinstatement of cocaine seeking in male and female rats

被引：0

作者：

Mankame, Sharvari ^{[1
]}

Worobey, Samantha J. ^{[1
]}

Sacko, Tyler J. ^{[1
]}

Pierce, Christopher ^{[1
]}

Swinford-Jackson, Sarah E. ^{[2
,3
]}

机构：

[1] Rutgers State Univ, Robert Wood Johnson Med Sch, Brain Hlth Inst, Piscataway, NJ 08854 USA

[2] Rutgers Hlth, Brain Hlth Inst, RWJMS Res Bldg,Room 160,683 Hoes Lane West, Piscataway, NJ 08854 USA

[3] Rutgers Hlth, Dept Psychiat, RWJMS Res Bldg,Room 160,683 Hoes Lane West, Piscataway, NJ 08854 USA

来源：

NEUROSCIENCE LETTERS | 2024年 / 836卷

关键词：

Cocaine; Deep brain stimulation; Nucleus accumbens; Reinstatement; Sex differences; SELF-ADMINISTERED COCAINE; SEX-DIFFERENCES; NUCLEUS-ACCUMBENS; GENDER-DIFFERENCES; DRUG SEEKING; BEHAVIOR; PROGESTERONE; ACQUISITION; ESTROGEN; RELAPSE;

D O I：

10.1016/j.neulet.2024.137888

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There are currently no FDA-approved treatments for cocaine use disorder. Recent preclinical and clinical studies showed that deep brain stimulation (DBS) in limbic regions reduced drug seeking behavior. Our previous work indicated that DBS of the nucleus accumbens shell attenuated reinstatement of cocaine seeking, a model of relapse, in male rats. The current experiments were designed to evaluate the effect of electrical DBS on cocaine reinstatement in female rats across the estrous cycle. Rats were allowed to self-administer cocaine and lever responding was subsequently extinguished. Cocaine seeking was reinstated by an acute injection of experimenter-delivered cocaine. The effect of nucleus accumbens shell DBS vs. sham stimulation on cocaine- primed reinstatement was evaluated in female and male rats using a within-subjects counterbalanced design. Consistent with previous work, accumbens shell DBS suppressed cocaine seeking in male rats. In sharp contrast, accumbens shell DBS had no effect on cocaine reinstatement in female rats evaluated in either the estrus or non- estrus phases. These results suggest that changes across the estrous cycle are not responsible for the differences in the effect of DBS on cocaine reinstatement between female and male rats.

引用

页数：6

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