Influence of apolipoprotein E gene polymorphisms on coronary artery disease in patients undergoing coronary angiography

Objective: Previous studies have shown that apolipoprotein E (ApoE) gene polymorphisms have an impact on coronary artery disease(CAD). However, many studies have small sample sizes and different conclusions. The purpose was to retrospectively study the influence of ApoE gene polymorphisms on CAD. Methods: This study assessed the influence of different ApoE genotypes on coronary heart disease in patients who received coronary angiography and used multivariate logistic regression to assess the influence of different ApoE genotypes on CAD. Results: Patients with different ApoE genotypes had no obvious differences in the incidence of hypertension, diabetes or obesity(P > 0.05). Patients with e2/e2 had higher incidence of hypertriglyceridemia than patients with other ApoE genotypes, while patients with e3/e3 had a lower incidence of hypertriglyceridemia than those with e3/e4,e4/e4, e2/e3 and e2/e2(P < 0.05). Patients with e3/e4, e4/e4, e3/e3 and e2/e2 had no significant differences in the severity or incidence of CAD (P > 0.05). e2/e4 and e2/e3 reduced the risk of high LDL-C, and reduced the severity and incidence of coronary heart(P < 0.05). e2/e3 reduced risk of premature coronary artery disease(PCAD)(P < 0.05). e2/e3 reduced risk of CAD in patients age <45,age at 60-74 and age >= 74, while e2/e4 reduced risk of CAD in patients age >= 74(P < 0.05). Conclusion: Patients with e3/e4, e4/e4,e3/e3 and e2/e2 had no significant differences in the severity and occurrence of CAD. Compared to the isoform e3 (e3/e3), isoform e4 did not increased the severity and occurrence of CAD. Compared with ApoE other genotypes, e2/e3 and e2/e4 reduced the risk of high LDL-C and the severity and occurrence of CAD.