"Naked Nickel"-Catalyzed Amination of Heteroaryl Bromides

被引：3
|
作者：
Saeb, Rakan [1 ]
Boulenger, Bryan [1 ]
Cornella, Josep [1 ]
机构：
[1] Max Planck Inst Kohlenforsch, Dept Organometall Chem, D-45470 Mulheim, North Rhine Wes, Germany
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 28期
关键词：
ARYL; PRECATALYST; PALLADIUM;
D O I：
10.1021/acs.orglett.4c01738
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this Letter, we report that the air-stable "naked nickel" [Ni((4-tBu)stb)(3)] is a competent catalyst in thermal C-N bond formation between (hetero)aryl bromides and N-based nucleophiles. The catalytic system is characterized by a "naked nickel" complex and Zn and by the absence of external light sources, photocatalysts, exogenous ligands, and electrical setups. Upon application of this method, various heteroaryls bearing Lewis-basic heteroatoms can be accommodated and directly aminated with a set of primary and secondary amines.
引用
收藏
页码：5928 / 5933
页数：6
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