Interfacing DNA and Aptamers with Gold Nanoparticles: From Fundamental Colloid and Interface Sciences to Biosensors

被引:6
作者
Ding, Yuzhe [1 ]
Liu, Juewen [1 ]
机构
[1] Univ Waterloo, Waterloo Inst Nanotechnol, Dept Chem, Waterloo, ON N2L 3G1, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
Aptamers; Biosensors; Gold nanoparticles; SELEX; Bioconjugation; SINGLE-STRANDED-DNA; IN-VITRO SELECTION; COLORIMETRIC DETECTION; THIOLATED DNA; QUANTITATIVE FUNCTIONALIZATION; SURFACE SCIENCE; ADSORPTION; DENSITY; PH; CONJUGATION;
D O I
10.1002/cjoc.202400113
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Interfacing DNA oligonucleotides and DNA aptamerswith gold nanoparticles has generated numerous functional hybrid materials for sensing, self-assembly and drug delivery applications. Our lab has been working in this area for 15 years. In this article, the current un-derstanding of the adsorption of DNA to gold nanoparticles is summarized, and related applicationsin bioconjugation of DNA to gold surfaceis described. In addition, problems of using gold nanoparticles to signaling aptamer binding arediscussed. Finally, re-selection of aptamers for previously reported targets using the library-immobilization method is reviewed.
引用
收藏
页码:2391 / 2400
页数:10
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