The impact of biomolecule interactions on the cytotoxic effects of rhenium (I) tricarbonyl complexes

被引:1
作者
de Lavor, Tayna Saraiva [1 ]
Teixeira, Maria Henriqueta Silvestre [2 ]
de Matos, Patricia Alves [1 ]
Lino, Ricardo Campos [2 ]
Silva, Clara Maria Faria [2 ]
do Carmo, Marcos Eduardo Gomes [3 ]
Beletti, Marcelo Emilio [4 ]
Patrocinio, Antonio Otavio T. [3 ]
de Oliveira Junior, Robson Jose [2 ]
Tsubone, Tayana Mazin [1 ]
机构
[1] Univ Fed Uberlandia UFU, Lab Interdisciplinar Fototerapia & Biomol LIFeBio, Inst Quim IQ, Uberlandia, MG, Brazil
[2] Univ Fed Uberlandia UFU, Lab Citogenet, Inst Biotecnol IBTEC, Uberlandia, MG, Brazil
[3] Univ Fed Uberlandia, Chem Inst, Lab Photochem & Mat Sci, Uberlandia, MG, Brazil
[4] Univ Fed Uberlandia UFU, Inst Ciencias Biomed ICBIM, Uberlandia, MG, Brazil
关键词
Anti-cancer drugs; Rhenium complexes; Biomolecules; Cytotoxicity; Drug design; Organometallic complexes; ANTICANCER ACTIVITY; DNA INTERACTIONS; BINDING; DERIVATIVES; DOCKING; PHOTOPHYSICS; MECHANISM; ACIDS;
D O I
10.1016/j.jinorgbio.2024.112600
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rhenium complexes show great promise as anticancer drug candidates. Specifically, compounds with a Re(CO)(3)(NN)(py)(+) core in their architecture have shown cytotoxicity equal to or greater than that of well-established anticancer drugs based on platinum or organic molecules. This study aimed to evaluate how the strength of the interaction between rhenium(I) tricarbonyl complexes fac-[Re(CO)(3)(NN)(py)](+), NN = 1,10-phenanthroline (phen), dipyrido[3,2-f:2 ',3 '-h]quinoxaline (dpq) or dipyrido[3,2-a:2 ' 3'-c]phenazine (dppz) and biomolecules (protein, lipid and DNA) impacted the corresponding cytotoxic effect in cells. Results showed that fac-[Re(CO)(3)(dppz)(py)](+) has higher Log P-o/w and binding constant (K-b) with biomolecules (protein, lipid and DNA) compared to complexes of fac-[Re(CO)(3)(phen)(py)](+) and fac-[Re(CO)(3)(dpq)(py)](+). As consequence, fac-[Re(CO)(3)(dppz)(py)](+) exhibited the highest cytotoxicity (IC50 = 8.5 mu M for HeLa cells) for fac-[Re(CO)(3)(dppz)(py)](+) among the studied compounds (IC50 > 15 mu M). This highest cytotoxicity of fac-[Re(CO)(3)(dppz)(py)](+) are probably related to its lipophilicity, higher permeation of the lipid bilayers of cells, and a more potent interaction of the dppz ligand with biomolecules (protein and DNA). Our findings open novel avenues for rational drug design and highlight the importance of considering the chemical structures of rhenium complexes that strongly interact with biomolecules (proteins, lipids, and DNA).
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页数:16
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