High pathogenic avian influenza A(H5) viruses of clade 2.3.4.4b in Europe-Why trends of virus evolution are more difficult to predict

被引：39

作者：

Fusaro, Alice ^{[1
]}

Zecchin, Bianca ^{[1
]}

Giussani, Edoardo ^{[1
]}

Palumbo, Elisa ^{[1
]}

Agueero-Garcia, Montserrat ^{[2
]}

Bachofen, Claudia ^{[3
]}

Balint, Adam ^{[4
]}

Banihashem, Fereshteh ^{[5
]}

Banyard, Ashley C. ^{[6
]}

Beerens, Nancy ^{[7
]}

Bourg, Manon ^{[8
]}

Briand, Francois-Xavier ^{[9
]}

Broejer, Caroline ^{[10
]}

Brown, Ian H. ^{[6
]}

Brugger, Brigitte ^{[11
]}

Byrne, Alexander M. P. ^{[6
]}

Cana, Armend ^{[12
]}

Christodoulou, Vasiliki ^{[13
]}

Dirbakova, Zuzana ^{[14
]}

Fagulha, Teresa ^{[15
]}

Fouchier, Ron A. M. ^{[16
]}

Garza-Cuartero, Laura ^{[17
]}

Georgiades, George ^{[18
]}

Gjerset, Britt ^{[19
]}

Grasland, Beatrice ^{[9
]}

Groza, Oxana ^{[20
]}

Harder, Timm ^{[21
]}

Henriques, Ana Margarida

Hjulsager, Charlotte Kristiane ^{[22
]}

Ivanova, Emiliya ^{[23
]}

Janeliunas, Zygimantas ^{[24
]}

Krivko, Laura ^{[25
]}

Lemon, Ken ^{[26
]}

Liang, Yuan ^{[27
]}

Lika, Aldin ^{[28
]}

Malik, Peter ^{[4
]}

McMenamy, Michael J.

Nagy, Alexander ^{[29
]}

Nurmoja, Imbi ^{[30
]}

Onita, Iuliana ^{[31
]}

Pohlmann, Anne

Revilla-Fernandez, Sandra

Sanchez-Sanchez, Azucena ^{[2
,32
]}

Savic, Vladimir ^{[33
]}

Slavec, Brigita ^{[34
]}

Smietanka, Krzysztof ^{[35
]}

Snoeck, Chantal J. ^{[36
]}

Steensels, Mieke ^{[37
]}

Svansson, Vilhjalmur ^{[38
]}

Swieton, Edyta ^{[35
]}

机构：

[1] Ist Zooprofilatt Sperimentale Venezie, European Reference Lab EURL Avian Influenza & New, Viale Univ 10, I-35020 Padua, Italy

[2] Minist Agr Fisheries & Food, Lab Cent Vet LCV, Ctra M-106,Km 1,4 Algete, Madrid 28110, Spain

[3] FDHA Inst Virol & Immunol IVI, Fed Dept Home Affairs, Sensemattstr 293, CH-3147 Mittelhausern, Switzerland

[4] Natl Food Chain Safety Off, Lab Virol, Vet Diagnost Directorate NEBIH, Tabornok Utca 2, H-1143 Budapest, Hungary

[5] Natl Vet Inst SVA, Dept Microbiol, Travvagen 20, S-75189 Uppsala, Sweden

[6] Anim & Plant Hlth Agcy Weybridge, WOAH FAO Int Reference Lab Avian Influenza & Newc, Dept Virol, Woodham Lane, Addlestone KT15 3NB, Surrey, England

[7] Wageningen Biovet Res, Dept Virol, Houtribweg 39, NL-8221 RA Lelystad, Netherlands

[8] Luxembourgish Vet & Food Adm ALVA, State Vet Lab, Rue Louis Rech, L-3555 Dudelange, Luxembourg

[9] Agence Natl Securite Sanit Alimentat Environm & T, Lab Ploufragan Plouzane Niort, Unite Virol Immunol Parasitol Avaires & Cunicoles, 41 Rue Beaucemaine,BP 53, F-29280 Ploufragan, France

[10] Natl Vet Inst SVA, Dept Pathol & Wildlife Dis, Travvagen 20, S-75189 Uppsala, Sweden

[11] Iceland Food & Vet Author, Austurvegur 64, IS-800 Selfoss, Iceland

[12] Kosovo Food & Vet Agcy, Kosovo Food & Vet Lab, Sect Serol & Mol Diagnost, Str Lidhja & Pejes, Prishtina 10000, Kosovo

[13] Sect Vet Serv, Lab Anim Hlth Virol, 79 Athalassa Ave Aglantzia, CY-1417 Nicosia, Cyprus

[14] State Vet Inst, Dept Anim Hlth, Drahami 918, Zvolen 96086, Slovakia

[15] Inst Nacl Invest Agr & Vet, INIAV IP, Ave Republ, P-2784505 Oeiras, Portugal

[16] Erasmus MC, Dept Virosci, Dr Molewaterpl 40, NL-3015 GD Rotterdam, Netherlands

[17] Cent Vet Res Lab, Dept Agr Food & Marine, Backweston Campus,Stacumny Lane, Celbridge W23 X3PH, Kildare, Ireland

[18] Thessaloniki Vet Ctr TVC, Dept Avian Dis, 26th October St 80, Thessaloniki 54627, Greece

[19] Norwegian Vet Inst, Immunol & Virol Dept, Arboretveien 57,Oslo Pb 64, N-1431 As, Norway

[20] Republican Ctr Hlth Promot, 3 St Murelor, Kishinev 2051, Moldova

[21] Friedrich Loeffler Inst, Inst Diagnost Virol, Sudufer 10, D-17493 Greifswald Insel Riems, Germany

[22] Statens Serum Inst, Dept Virus & Microbiol Special Diagnost, 5 Artillerivej, DK-2300 Copenhagen, Denmark

[23] Natl Diagnost & Res Vet Med Inst, Natl Reference Lab Avian Influenza & Newcastle Di, 190 Lomsko Shose Blvd, Sofia 1231, Bulgaria

[24] Natl Food & Vet Risk Assessment Inst NFVRAI, Kairiukscio Str 10, LT-08409 Vilnius, Lithuania

[25] Inst Food Safety Anim Hlth & Environm BIOR, Lab Microbil & Pathol, 3 Lejupes St, LV-1076 Riga, Latvia

[26] Agri Food & Biosci Inst AFBI, Vet Sci Div, Virol Mol Diagnost Lab, Dept Virol, Stoney Rd, Belfast BT4 3SD, Antrim, North Ireland

[27] Univ Copenhagen, Dept Vet Anim Sci, Gronnegardsvej 15, DK-1870 Frederiksberg, Denmark

[28] Food Safety & Vet Inst, Dept Anim Hlth, Rruga Aleksander Moisiu 10, Tirana 1001, Albania

[29] State Vet Inst Prague, Dept Mol Biol, Sidlistni 136-24, Prague 16503 6, Lysolaje, Czech Republic

[30] Natl Ctr Lab Res & Risk Assessment LABRIS, Kreutzwaldi 30, EE-51006 Tartu, Estonia

[31] Inst Diag & Anim Hlth, Str Dr Staicovici 63, Bucharest 050557, Romania

[32] Austrian Agcy Hlth & Food Safety AGES, Inst Vet Dis Control, Robert Koch Gasse 17, A-2340 Modling, Austria

[33] Croatian Vet Inst, Poultry Ctr, Heinzelova 55, Zagreb 10000, Croatia

[34] Univ Ljubljana, Natl Vet Inst, Vet Fac, Gerbiceva 60, Ljubljana 1000, Slovenia

[35] Natl Vet Res Inst, Dept Poultry Dis, Al Partyzantow 57, PL-24100 Pulawy, Poland

[36] Luxembourg Inst Hlth LIH, Dept Infect & Immun, 29 Rue Henri Koch, L-4354 Esch Sur Alzette, Luxembourg

[37] Sciensano, Avian Virol & Immunol, Rue Groeselenberg 99, B-1180 Uccle, Belgium

[38] Univ Iceland, Biomed Ctr, Inst Expt Pathol, Keldnavegi 3 112 Reykjavik Ssn 650269 4549, IS-851 Keldur, Iceland

[39] Finnish Food Author, Anim Hlth Diagnost Unit, Vet Virol, Mustialankatu 3, FI-00790 Helsinki, Finland

[40] European Ctr Dis Prevent & Control, Gustav II :s Blvd 40, S-16973 Solna, Sweden

[41] European Food Safety Author, Via Carlo Magno 1A, I-43126 Parma, Italy

来源：

VIRUS EVOLUTION | 2024年 / 10卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

high pathogenic avian influenza A(H5) viruses; phylodynamics; Europe; reassortments; spatial spread; SINGLE-AMINO-ACID; A VIRUS; NS1; PROTEIN; FILAMENTOUS MORPHOLOGY; AMANTADINE-RESISTANCE; VIRAL POLYMERASE; MOLECULAR-BASIS; MATRIX PROTEIN; HIGH VIRULENCE; GLOBAL SPREAD;

D O I：

10.1093/ve/veae027

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Since 2016, A(H5Nx) high pathogenic avian influenza (HPAI) virus of clade 2.3.4.4b has become one of the most serious global threats not only to wild and domestic birds, but also to public health. In recent years, important changes in the ecology, epidemiology, and evolution of this virus have been reported, with an unprecedented global diffusion and variety of affected birds and mammalian species. After the two consecutive and devastating epidemic waves in Europe in 2020-2021 and 2021-2022, with the second one recognized as one of the largest epidemics recorded so far, this clade has begun to circulate endemically in European wild bird populations. This study used the complete genomes of 1,956 European HPAI A(H5Nx) viruses to investigate the virus evolution during this varying epidemiological outline. We investigated the spatiotemporal patterns of A(H5Nx) virus diffusion to/from and within Europe during the 2020-2021 and 2021-2022 epidemic waves, providing evidence of ongoing changes in transmission dynamics and disease epidemiology. We demonstrated the high genetic diversity of the circulating viruses, which have undergone frequent reassortment events, providing for the first time a complete overview and a proposed nomenclature of the multiple genotypes circulating in Europe in 2020-2022. We described the emergence of a new genotype with gull adapted genes, which offered the virus the opportunity to occupy new ecological niches, driving the disease endemicity in the European wild bird population. The high propensity of the virus for reassortment, its jumps to a progressively wider number of host species, including mammals, and the rapid acquisition of adaptive mutations make the trend of virus evolution and spread difficult to predict in this unfailing evolving scenario.

引用

页数：18

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