The Importance of Microbiota and Fecal Microbiota Transplantation in Pancreatic Disorders

被引:29
作者
Boicean, Adrian [1 ]
Ichim, Cristian [1 ]
Todor, Samuel Bogdan [1 ]
Anderco, Paula [1 ]
Popa, Mirela Livia [1 ]
机构
[1] Lucian Blaga Univ Sibiu, Fac Med, Sibiu 550169, Romania
基金
英国科研创新办公室;
关键词
microbiota; fecal microbiota transplantation; pancreatitis; pancreatic cancer; T1D; CLOSTRIDIUM-DIFFICILE INFECTION; GUT MICROBIOTA; INTESTINAL MICROBIOTA; DYSBIOSIS; EXOCRINE; THERAPY; DISEASE;
D O I
10.3390/diagnostics14090861
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The role of the intestinal microbiota in the diagnosis and treatment of pancreatic diseases is increasingly significant. Consequently, fecal microbiota transplantation (FMT) is emerging as a promising therapeutic avenue for various pancreatic disorders, including cancer, pancreatitis, and type 1 diabetes (T1D). This innovative procedure entails transferring gut microbiota from healthy donors to individuals affected by pancreatic ailments with the potential to restore intestinal balance and alleviate associated symptoms. FMT represents a pioneering approach to improve patient outcomes in pancreatic diseases, offering tailored treatments customized to individual microbiomes and specific conditions. Recent research highlights the therapeutic benefits of targeting the gut microbiota for personalized interventions in pancreatic disorders. However, a comprehensive understanding of the intricate interplay between gut microbiota and pancreatic physiology warrants further investigation. The necessity for additional studies and research endeavors remains crucial, especially in elucidating both adult and pediatric cases affected by pathological pancreatic conditions.
引用
收藏
页数:15
相关论文
共 99 条
[1]   Precise quantification of bacterial strains after fecal microbiota transplantation delineates long-term engraftment and explains outcomes [J].
Aggarwala, Varun ;
Mogno, Ilaria ;
Li, Zhihua ;
Yang, Chao ;
Britton, Graham J. ;
Chen-Liaw, Alice ;
Mitcham, Josephine ;
Bongers, Gerold ;
Gevers, Dirk ;
Clemente, Jose C. ;
Colombel, Jean-Frederic ;
Grinspan, Ari ;
Faith, Jeremiah .
NATURE MICROBIOLOGY, 2021, 6 (10) :1309-+
[2]   Recommendations for stool donor selection for fecal microbiota transplant. Consensus document endorsed by the Catalan Society of Digestology, Catalan Society of Infectious diseases and Clinical microbiology and the GEMBIOTA group from Spanish Society of Infectious Diseases and Clinical Microbiology [J].
Aira, Andrea ;
Arajol, Claudia ;
Casals-Pascual, Climent ;
Gonzalez-Suarez, Begona ;
Marti, Silvia ;
Angeles Dominguez, M. ;
Guardiola, Jordi ;
Soriano, Alex .
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2022, 40 (03) :142-146
[3]   The Gut Microbiome in Pancreatic Disease [J].
Akshintala, Venkata S. ;
Talukdar, Rupjyoti ;
Singh, Vikesh K. ;
Goggins, Michael .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2019, 17 (02) :290-295
[4]   Gut microbiota predicts severity and reveals novel metabolic signatures in acute pancreatitis [J].
Ammer-Herrmenau, Christoph ;
Antweiler, Kai L. ;
Asendorf, Thomas ;
Beyer, Georg ;
Buchholz, Soeren M. ;
Cameron, Silke ;
Capurso, Gabriele ;
Damm, Marko ;
Dang, Linh ;
Frost, Fabian ;
Gomes, Antonio ;
Hamm, Jacob ;
Henker, Robert ;
Hoffmeister, Albrecht ;
Meinhardt, Christian ;
Nawacki, Lukasz ;
Nunes, Vitor ;
Panyko, Arpad ;
Pardo, Cesareo ;
Phillip, Veit ;
Pukitis, Aldis ;
Rasch, Sebastian ;
Riekstina, Diana ;
Rinja, Ecaterina ;
Ruiz-Rebollo, Maria Lourdes ;
Sirtl, Simon ;
Weingarten, Mark ;
Sandru, Vasile ;
Woitalla, Julia ;
Ellenrieder, Volker ;
Neesse, Albrecht .
GUT, 2024, 73 (03) :485-495
[5]   Fecal microbiota transplantation in disease therapy [J].
Antushevich, Hanna .
CLINICA CHIMICA ACTA, 2020, 503 :90-98
[6]  
Bakken Johan S., 2015, Microbial Ecology in Health and Disease, V26, P27657, DOI [10.3402/mehd.v26.27657, 10.3402/mehd.v26.27657]
[7]   Real-World Patient Experience With Pancreatic Enzyme Replacement Therapy in the Treatment of Exocrine Pancreatic Insufficiency [J].
Barkin, Jodie A. ;
Harb, Diala ;
Kort, Jens ;
Barkin, Jamie S. .
PANCREAS, 2024, 53 (01) :e16-e21
[8]   Challenges and costs of donor screening for fecal microbiota transplantations [J].
Benard, Melanie, V ;
de Bruijn, Clara M. A. ;
Fenneman, Aline C. ;
Wortelboer, Koen ;
Zeevenhoven, Judith ;
Rethans, Bente ;
Herrema, Hilde J. ;
van Gool, Tom ;
Nieuwdorp, Max ;
Benninga, Marc A. ;
Ponsioen, Cyriel Y. .
PLOS ONE, 2022, 17 (10)
[9]  
Bibbò S, 2017, MINERVA GASTROENT D, V63, P420, DOI 10.23736/S1121-421X.17.02374-1
[10]   Fecal Microbiota Transplantation in Liver Cirrhosis [J].
Boicean, Adrian ;
Birlutiu, Victoria ;
Ichim, Cristian ;
Brusnic, Olga ;
Onisor, Danusia Maria .
BIOMEDICINES, 2023, 11 (11)