Hepatitis B-CpG Vaccine Series for Healthcare Workers Who Are Hepatitis B Vaccine Nonresponders

被引：2

作者：

Russ, Rachel K. ^{[1
]}

Vandehei, Haley M. ^{[2
]}

Golovkina, Maria, I ^{[1
]}

Mogallapalli, Harshitha ^{[3
]}

Caldera, Freddy ^{[3
]}

Hayney, Mary S. ^{[1
]}

机构：

[1] Univ Wisconsin Madison, Sch Pharm, 777 Highland Ave, Madison, WI 53705 USA

[2] UW Hlth, Employee Hlth Serv, Madison, WI USA

[3] Univ Wisconsin Madison, Sch Med & Publ Hlth, Dept Med, Div Gastroenterol & Hepatol, Madison, WI USA

来源：

CLINICAL INFECTIOUS DISEASES | 2024年 / 79卷 / 02期

关键词：

hepatitis B vaccine; healthcare workers; nonresponders; seroprotections; hepatitis B vaccine-CpG adjuvant;

D O I：

10.1093/cid/ciae320

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This prospective study enrolled healthcare workers (HCWs) who were nonresponders following at least 5 doses of aluminum-adjuvanted hepatitis B vaccine who received the 2-dose Heplisav-B (HepB-CpG) (Dynavax Technologies Corporation, Emeryville, CA) series. After 2 doses of HepB-CpG, 43/47 (91%) participants, and with 1 dose, 41/49 (84%) responded. HepB-CpG could be the preferred vaccine in HCW nonresponders.Clinical Trials Registration. Clinicaltrials.gov NCT04456504.

引用

页码：562 / 563

页数：2

共 5 条

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[3]

Schillie S, 2018, MMWR RECOMM REP, V67, P1, DOI 10.15585/mmwr.rr6701a1

[4] Preventing hepatitis B virus infection among healthcare professionals: potential impact of a 2-dose versus 3-dose vaccine [J].

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