Five new meroterpenes from the seeds of Psoralea corylifolia and their diacylglycerol acyltransferase activity

被引：0

作者：

Shao, Xiao-Jing ^{[1
]}

Xiu, Meng-Xue ^{[2
]}

Wang, Xue-Hui ^{[1
]}

Xu, Wen-Hui ^{[1
]}

Xiao, Ying-Xiao ^{[1
]}

Gao, Yuan ^{[1
]}

Jiang, Yi-Ran ^{[1
]}

Bei, Tian-Tian ^{[1
]}

Lee, Hyun-Sun ^{[3
]}

Cui, Long ^{[1
]}

机构：

[1] Beihua Univ, Coll Pharm, Jilin 132013, Jilin, Peoples R China

[2] Baicheng Med Coll, Coll Pharm, Baicheng 137000, Jilin, Peoples R China

[3] Korea Res Inst Biosci & Biotechnol KRIBB, Mol Canc Res Ctr, 685-1 Yangcheongri, Cheongwongun 363883, Chungbuk, South Korea

来源：

PHYTOCHEMISTRY LETTERS | 2024年 / 61卷

关键词：

Psoralea corylifolia; Meroterpenes; DGAT; Inhibitory; CHEMICAL-CONSTITUENTS; BAKUCHIOL; DERIVATIVES;

D O I：

10.1016/j.phytol.2024.03.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new meroterpenes (1-5), have been isolated and elucidated from the seeds of Psoralea corylifolia together with four known bakuchiol analogues (6-9). The structures of these compounds were elucidated by extensive spectroscopic analysis (NMR, HRESIMS and CD). Among them, compounds 1 - 9 were found to exhibit selective inhibitory activity on DGAT1 with IC 50 values ranging from 54.4 +/- 1.3 to 98.2 +/- 1.1 mu M.

引用

页码：16 / 20

页数：5

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