Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

被引：3
作者：
Hovis, Gabrielle [1 ]
Chandra, Neha [2 ]
Kejriwal, Nidhi [2 ]
Hsieh, Kaleb Jia-Yi [2 ]
Chu, Alison [3 ]
Yang, Isaac [1 ,4 ,5 ,6 ,7 ]
Wadehra, Madhuri [2 ,7 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Div Neonatol & Dev Biol, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, Los Angeles, CA 90095 USA
[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Head & Neck Surg, Los Angeles, CA 90095 USA
[6] Harbor UCLA Med Ctr, Lundquist Inst, Torrance, CA 90502 USA
[7] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 11期
关键词：
glioblastoma; endothelium; angiogenesis; tumor marker; BONE MORPHOGENETIC PROTEIN; GROWTH-FACTOR; ANTIANGIOGENIC THERAPY; TUMOR-GROWTH; PHASE-II; C-MET; ANGIOGENESIS; SORAFENIB; BEVACIZUMAB; GLIOMA;
D O I：
10.3390/ijms25116118
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glioblastoma is a highly aggressive neoplasm and the most common primary malignant brain tumor. Endothelial tissue plays a critical role in glioblastoma growth and progression, facilitating angiogenesis, cellular communication, and tumorigenesis. In this review, we present an up-to-date and comprehensive summary of the role of endothelial cells in glioblastomas, along with an overview of recent developments in glioblastoma therapies and tumor endothelial marker identification.
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页数：20
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