Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

被引：4
|
作者：
Yavuz, Burcak [1 ]
Mutlu, Esra Cansever [2 ]
Ahmed, Zubair [3 ]
Ben-Nissan, Besim [4 ]
Stamboulis, Artemis [2 ]
机构：
[1] Altinbas Univ, Vocat Sch Hlth Serv, TR-34147 Istanbul, Turkiye
[2] Univ Birmingham, Coll Engn & Phys Sci, Sch Met & Mat, Biomat Res Grp, Birmingham B15 2TT, England
[3] Univ Birmingham, Inst Inflammat & Ageing, Neurosci & Ophthalmol, Birmingham B15 2TT, England
[4] Univ Technol Sydney, Sch Life Sci, Translat Biomat & Med Grp, POB 123, Broadway, NSW 2007, Australia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 11期
关键词：
nerve regeneration; non-coding RNAs; exosome; traumatic brain injury; blood-brain barrier; RETINAL GANGLION-CELLS; TRAUMATIC BRAIN-INJURY; SPINAL-CORD-INJURY; STROMAL CELLS; IN-VITRO; FUNCTIONAL RECOVERY; NEUROTROPHIC FACTOR; BLOOD-CELLS; EXOSOMES; THERAPY;
D O I：
10.3390/ijms25115863
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have been associated with the therapeutic effects observed in cell-based therapies, and they also contribute to tissue regeneration following injury, such as in orthopaedic surgery cases. This review explores the involvement of EVs in nerve regeneration, their potential as drug carriers, and their significance in stem cell research and cell-free therapies. It underscores the importance of bioengineers comprehending and manipulating EV activity to optimize the efficacy of tissue engineering and regenerative therapies.
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页数：26
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