Epimedium Linn: A Comprehensive Review of Phytochemistry, Pharmacology, Clinical Applications and Quality Control

被引：10

作者：

Chen, Xiao-Lin ^{[1
]}

Li, Shi-Xing ^{[1
]}

Ge, Teng ^{[2
]}

Zhang, Dong-Dong ^{[1
]}

Wang, Hai-Fang ^{[1
]}

Wang, Wei ^{[2
]}

Li, Yu-Ze ^{[1
]}

Song, Xiao-Mei ^{[1
]}

机构：

[1] Shaanxi Univ Chinese Med, Sch Pharm, Shaanxi Key Lab Res & Applicat Taibai Qi Yao, Xianyang 712046, Peoples R China

[2] Shaanxi Prov Key Lab Integrated Tradit Chinese & W, Xianyang 712046, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2024年 / 21卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Epimedium Linn; phytochemistry; pharmacological; clinical application; quality control; FLAVONOL GLYCOSIDE; AERIAL PARTS; KOREANUM NAKAI; PROCESSED EPIMEDIUM; PROPOLIS FLAVONE; DIABETIC-RATS; ICARISIDE II; NITRIC-OXIDE; AGING RATS; IN-VITRO;

D O I：

10.1002/cbdv.202400846

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epimedium genus is a traditional Chinese medicine, which has functions of tonifying kidney and yang, strengthening tendons and bones, dispelling wind and emoving dampness. It is mainly used for the treatment of impotence and spermatorrhea, osteoporosis, Parkinson's, Alzheimer's, and cardiovascular diseases. The aim of this review is to provide a systematic summary of the phytochemistry, pharmacology, and clinical applications of the Epimedium Linn. In this paper, the relevant literature on Epimedium Linn. was collected from 1987 to the present day, and more than 274 chemical constituents, including flavonoids, phenylpropanoids, lignans, phenanthrenes, and others, were isolated from this genus. Modern pharmacological studies have shown that Epimedium Linn. has osteoprotective, neuroprotective, cardiovascular protective, and immune enhancing pharmacological effects. In addition, Epimedium Linn. has been commonly used to treat osteoporosis, erectile dysfunction, hypertension and cardiovascular disease. In this paper, the distribution of resources, chemical compositions, pharmacological effects, clinical applications and quality control of Epimedium Linn. are progressed to provide a reference for further research and development of the resources of this genus.

引用

页数：39

共 217 条

[1] Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy [J].

Bai, Long ;

Liu, Yanpeng ;

Zhang, Xiaohui ;

Chen, Peiru ;

Hang, Ruiqiang ;

Xiao, Yin ;

Wang, Jing ;

Liu, Changsheng .

BIOMATERIALS, 2023, 297

[2]

Bi Z., 2020, THESIS GANSU U CHINS

[3]

Bian Y.Q., 2014, THESIS NANJING U CHI

[4]

Cai H.M., 2019, THESIS ANHUI U CHINE

[5]

Chai S.W., 2016, Tianjin J. Trad. Chin. Med., V33, P114

[6] New prenylflavones from the leaves of Epimedium sagittatum [J].

Chen, CC ;

Huang, YL ;

Sun, CM ;

Shen, CC ;

Ko, FN ;

Teng, CM .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (04) :412-414

[7] 8-Prenylkaempferol suppresses inducible nitric oxide synthase expression through interfering with JNK-mediated AP-1 pathway in murine macrophages [J].

Chen, Chien-Chih ;

Tsai, Pei-Chung ;

Wei, Bai-Luh ;

Chiou, Wen-Fei .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 590 (1-3) :430-436

[8]

Chen Dezhao, 2001, FLORA CHINA, P262

[9]

Chen J., 2022, THESIS ZUNYI MED U C

[10] Dynamic microwave-assisted extraction of flavonoids from Herba Epimedii [J].

Chen, Ligang ;

Jin, Haiyan ;

Ding, Lan ;

Zhang, Huarong ;

Li, Juan ;

Qu, Chenling ;

Zhang, Hanqi .

SEPARATION AND PURIFICATION TECHNOLOGY, 2008, 59 (01) :50-57

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