Evaluation of bioactivity, biocompatibility, and antibacterial properties of tricalcium silicate bone cement modified with wollastonite/ fluorapatite glass and glass-ceramic

This work ' s main objective is to assess the effects of wollastonite/fluorapatite glass (G) and glass -ceramic (GC) on tricalcium silicate ' s (TCS) bioactivity and physico-mechanical properties. To achieve this goal, 10 and 20 wt percent of G or GC were used in place of TCS. The constructed specimens were kept submerged in SBF solution for 4 weeks at a temperature of approximately 37 +/- 0.5 degrees C to create the hydroxyapatite layer (HA) on the cement paste surface and evaluate their biological behavior. Additionally measured were bulk density, apparent porosity, and compressive strength. The principal components had been studied using X-ray diffraction and Fourier transform infrared spectroscopy. An energy dispersive spectroscopy (EDS)-equipped scanning electron microscope (SEM) was used to examine the materials ' morphology. The antibacterial and cytotoxic properties were also evaluated. The findings demonstrated that during soaking in SBF, bulk density and porosity ranged from 1.38 to 1.5 g/cm 3 and from 44.99 to 39.12 %, respectively, and the results for compression strength varied from 65 to 88 MPa. The outcomes demonstrated that all of the prepared samples ' surfaces had the hydroxyapatite layer (HA) formed on them following their immersion in the biological fluid (SBF). Additionally, it was discovered that raising the percentage of GC (TCS/20GC) in synthetic samples improves TCS cement ' s physicomechanical and bioactivity characteristics. Furthermore, these substances had minimal cytotoxic effects on the typical fibroplast cell line of humans (BJ1), indicating their potential utility in dental applications. Ultimately, the antimicrobial test demonstrated good inhibitory behavior against the pathogens Bacillus cereus, Staphylococcus aureus, and Pseudomonas aeruginosa.