Histological Changes in the Popliteal Artery Wall in Patients with Critical Limb Ischemia

被引：0

作者：

Andercou, Octavian ^{[1
]}

Andrei, Maria Cristina ^{[2
]}

Gheban, Dan ^{[3
]}

Marian, Dorin ^{[4
]}

Coman, Horatiu ^{[5
]}

Oprea, Valentin Aron ^{[6
]}

Mihaileanu, Florin Vasile ^{[1
]}

Ciocan, Razvan ^{[1
]}

Cucuruz, Beatrix ^{[7
]}

Stancu, Bogdan ^{[1
]}

机构：

[1] Univ Med & Pharm Iuliu Hatieganu, Emergency Cty Hosp Cluj, Dept Surg, Cluj Napoca 400347, Romania

[2] Satu Mare Cty Emergency Hosp, Vasc Surg Dept, Satu Mare 440192, Romania

[3] Univ Med & Pharm Iuliu Hatieganu, Dept Pathol Anat, Cluj Napoca 400347, Romania

[4] Univ Med & Pharm Emil Palade, Emergency Cty Hosp Mures, Surg Dept 2, Targu Mures 540142, Romania

[5] Emergency Cty Hosp, Dept Vasc Surg, Cluj Napoca 400006, Romania

[6] Univ Med & Pharm Iuliu Hatieganu, Emergency Mil Hosp Cluj Napoca, Emergency Military Hospital Cluj Napoca, Cluj Napoca 400347, Romania

[7] Martha Maria Hosp Nuremberg, Dept Vasc Surg, D-90491 Nurnberg, Germany

来源：

DIAGNOSTICS | 2024年 / 14卷 / 10期

关键词：

diabetes mellitus; atherosclerosis; medial calcinosis; atherosclerotic plaque critical limb ischemia; VASCULAR CALCIFICATION; VULNERABLE PLAQUE; RISK-FACTORS; DISEASE; CLASSIFICATION; EPIDEMIOLOGY; MANAGEMENT; LESIONS;

D O I：

10.3390/diagnostics14100989

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: This prospective study aims to illustrate the histopathological arterial changes in the popliteal artery in peripheral arterial disease of the lower limbs. Material and method: A total of 60 popliteal artery segments taken from patients who had undergone lower limb amputation were examined between April and June 2023. The degree of arterial stenosis, medial calcinosis, and the vasa vasorum changes in the arterial adventitia were quantified. The presence of risk factors for atherosclerosis was also observed. Results: Atherosclerotic plaque was found in all of the examined segments. Medial calcinosis was observed in 40 (66.6%) of the arterial segments. A positive association between the degree of arterial stenosis and the vasa vasorum changes in the arterial adventitia was also found (p = 0.025). The level of blood sugar and cholesterol were predictive factors for the severity of atherosclerosis. Conclusions: Atherosclerosis and medial calcinosis are significant in patients who underwent lower limb amputation. Medial calcinosis causes damage to the arterial wall and leads to a reduction in responsiveness to dilator stimuli.

引用

页数：9

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