Correlation of 18F-BPA and 18F-FDG uptake in head and neck cancers

被引：23

作者：

Tani, Hitomi ^{[1
,3
]}

Kurihara, Hiroaki ^{[1
]}

Hiroi, Kenta ^{[1
]}

Honda, Natsuki ^{[1
]}

Yoshimoto, Mitsuyoshi ^{[2
]}

Kono, Yuzuru ^{[1
]}

Murakami, Ryusuke ^{[3
]}

Kumita, Shinichiro ^{[3
]}

Arai, Yasuaki ^{[1
]}

Itami, Jun ^{[4
]}

机构：

[1] Natl Canc Ctr, Dept Diagnost Radiol, Tokyo, Japan

[2] Natl Canc Ctr Hosp East, Div Funct Imaging, Chiba, Japan

[3] Nippon Med Sch, Dept Radiol, Tokyo 113, Japan

[4] Natl Canc Ctr, Dept Radiat Oncol, Tokyo, Japan

来源：

RADIOTHERAPY AND ONCOLOGY | 2014年 / 113卷 / 02期

关键词：

BPA; FDG; PET/CF; Head and neck tumor; BNCT; NEUTRON-CAPTURE THERAPY; AMINO-ACID TRANSPORTER; HIGH-GRADE GLIOMAS; RECURRENT HEAD; TARGET COMPOUND; TUMOR-TISSUE; FDG UPTAKE; PET; BNCT; BORONOPHENYLALANINE;

D O I：

10.1016/j.radonc.2014.11.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background and purpose: The aim of this study was to compare the accumulation of 4-borono-2-F-18-fluoro-phenylalanine (F-18-BPA) with that of F-18-fluorodeoxyglucose (F-18-FDG) in head and neck cancers, and to assess the usefulness of F-18-FDG PET for screening candidates for boron neutron capture therapy (BNCT). Material and methods: Twenty patients with pathologically proven malignant tumors of the head and neck were recruited from March 2012 to January 2014. All patients underwent both whole-body F-18-BPA PET/CF and F-18-FDG PET/CT within 2 weeks of each other. The uptakes of F-18-BPA and F-18-FDG at 1 h after injection were evaluated using the maximum standardized uptake value (SUVmax). Results: The accumulation of F-18-FDG was significantly correlated with that of F-18-BPA. The SUVmax of F-18-FDG >= 5.0 is considered to be suggestive of high F-18-BPA accumulation. Conclusions: F-18-FDG PET might be an effective screening method performed prior to F-18-BPA for selecting patients with head and neck cancer for treatment with BNCT. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：193 / 197

页数：5

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