Correlation of 18F-BPA and 18F-FDG uptake in head and neck cancers

被引：23
作者：
Tani, Hitomi [1 ,3 ]
Kurihara, Hiroaki [1 ]
Hiroi, Kenta [1 ]
Honda, Natsuki [1 ]
Yoshimoto, Mitsuyoshi [2 ]
Kono, Yuzuru [1 ]
Murakami, Ryusuke [3 ]
Kumita, Shinichiro [3 ]
Arai, Yasuaki [1 ]
Itami, Jun [4 ]
机构：
[1] Natl Canc Ctr, Dept Diagnost Radiol, Tokyo, Japan
[2] Natl Canc Ctr Hosp East, Div Funct Imaging, Chiba, Japan
[3] Nippon Med Sch, Dept Radiol, Tokyo 113, Japan
[4] Natl Canc Ctr, Dept Radiat Oncol, Tokyo, Japan
来源：
RADIOTHERAPY AND ONCOLOGY | 2014年 / 113卷 / 02期
关键词：
BPA; FDG; PET/CF; Head and neck tumor; BNCT; NEUTRON-CAPTURE THERAPY; AMINO-ACID TRANSPORTER; HIGH-GRADE GLIOMAS; RECURRENT HEAD; TARGET COMPOUND; TUMOR-TISSUE; FDG UPTAKE; PET; BNCT; BORONOPHENYLALANINE;
D O I：
10.1016/j.radonc.2014.11.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background and purpose: The aim of this study was to compare the accumulation of 4-borono-2-F-18-fluoro-phenylalanine (F-18-BPA) with that of F-18-fluorodeoxyglucose (F-18-FDG) in head and neck cancers, and to assess the usefulness of F-18-FDG PET for screening candidates for boron neutron capture therapy (BNCT). Material and methods: Twenty patients with pathologically proven malignant tumors of the head and neck were recruited from March 2012 to January 2014. All patients underwent both whole-body F-18-BPA PET/CF and F-18-FDG PET/CT within 2 weeks of each other. The uptakes of F-18-BPA and F-18-FDG at 1 h after injection were evaluated using the maximum standardized uptake value (SUVmax). Results: The accumulation of F-18-FDG was significantly correlated with that of F-18-BPA. The SUVmax of F-18-FDG >= 5.0 is considered to be suggestive of high F-18-BPA accumulation. Conclusions: F-18-FDG PET might be an effective screening method performed prior to F-18-BPA for selecting patients with head and neck cancer for treatment with BNCT. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：193 / 197
页数：5
相关论文
共 24 条
  • [1] Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer
    Barth, Rolf F.
    Vicente, M. Graca H.
    Harling, Otto K.
    Kiger, W. S., III
    Riley, Kent J.
    Binns, Peter J.
    Wagner, Franz M.
    Suzuki, Minoru
    Aihara, Teruhito
    Kato, Itsuro
    Kawabata, Shinji
    [J]. RADIATION ONCOLOGY, 2012, 7
  • [2] Identification of LAT4, a novel amino acid transporter with system L activity
    Bodoy, S
    Martín, L
    Zorzano, A
    Palacín, M
    Estévez, R
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (12) : 12002 - 12011
  • [3] Serial assessment of FDG-PET FDG uptake and functional volume during radiotherapy (RT) in patients with non-small cell lung cancer (NSCLC)
    Edet-Sanson, Agathe
    Dubray, Bernard
    Doyeux, Kaya
    Back, Adeline
    Hapdey, Sebastien
    Modzelewski, Romain
    Bohn, Pierre
    Gardin, Isabelle
    Vera, Pierre
    [J]. RADIOTHERAPY AND ONCOLOGY, 2012, 102 (02) : 251 - 257
  • [4] Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
    Fuchs, BC
    Bode, BP
    [J]. SEMINARS IN CANCER BIOLOGY, 2005, 15 (04) : 254 - 266
  • [5] L-type amino acid transporters LAT1 and LAT4 in cancer:: Uptake of 3-O-methyl-6-18F-fluoro-L-dopa in human adenocarcinoma and squamous cell carcinoma in vitro and in vivo
    Haase, Cathleen
    Bergmann, Ralf
    Fuechtner, Frank
    Hoepping, Alexander
    Pietzsch, Jens
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (12) : 2063 - 2071
  • [6] Boron neutron capture therapy (BNCT) for glioblastoma multiforme:: A phase II study evaluating a prolonged high-dose of boronophenylalanine (BPA)
    Henriksson, Roger
    Capala, Jacek
    Michanek, Annika
    Lindahl, Sten-Ake
    Satford, Leif G.
    Franzen, Lars
    Blomquist, Erik
    Westlin, Jan-Erik
    Bergenheim, A. Tommy
    [J]. RADIOTHERAPY AND ONCOLOGY, 2008, 88 (02) : 183 - 191
  • [7] CORRELATION OF GLUCOSE CONSUMPTION AND TUMOR-CELL DENSITY IN ASTROCYTOMAS - A STEREOTAXIC PET STUDY
    HERHOLZ, K
    PIETRZYK, U
    VOGES, J
    SCHRODER, R
    HALBER, M
    TREUER, H
    STURM, V
    HEISS, WD
    [J]. JOURNAL OF NEUROSURGERY, 1993, 79 (06) : 853 - 858
  • [8] Evaluation of performance of an accelerator-based BNCT facility for the treatment of different tumor targets
    Herrera, M. S.
    Gonzalez, S. J.
    Minsky, D. M.
    Kreiner, A. J.
    [J]. PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 2013, 29 (05): : 436 - 446
  • [9] Imahori Y, 1998, CLIN CANCER RES, V4, P1825
  • [10] Imahori Y, 1998, J NUCL MED, V39, P325
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