Improving STING agonist-based cancer therapy by inhibiting the autophagy-related protein VPS34

被引：0

作者：

Bartolini, Elisabetta ^{[1
]}

Van Moer, Kris ^{[1
]}

Janji, Bassam ^{[1
]}

机构：

[1] Luxembourg Inst Hlth LIH, Dept Canc Res, Tumor Immunotherapy & Microenvironm TIME Grp, 6A,rue Nicolas Ernest Barble, L-1210 Luxembourg City, Luxembourg

来源：

ONCOIMMUNOLOGY | 2024年 / 13卷 / 01期

关键词：

Autophagy; CCL5; CD8 T cells; CXCL10; immunotherapy; melanoma; NK cells; renal cell carcinoma; STING agonist; type I IFN response; VPS34; DNA SENSOR;

D O I：

10.1080/2162402X.2024.2364958

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have recently demonstrated that inhibiting VPS34 enhances T-cell-recruiting chemokines through the activation of the cGAS/STING pathway using the STING agonist ADU-S100. Combining VPS34 inhibitors with ADU-S100 increased cytokine release and improved tumor control in mouse models, suggesting a potential synergy between VPS34 inhibition and therapies based on STING agonists.

引用

页数：3

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