The Role of Mesenchymal Stromal Cells in the Treatment of Rheumatoid Arthritis

被引:3
作者
Bakinowska, Estera [1 ]
Bratborska, Aleksandra Wiktoria [2 ]
Kielbowski, Kajetan [1 ]
Cmil, Maciej [1 ]
Biniek, Wojciech Jerzy [1 ]
Pawlik, Andrzej [1 ]
机构
[1] Pomeranian Med Univ, Dept Physiol, PL-70111 Szczecin, Poland
[2] Poznan Univ Med Sci, Dept Internal Med, PL-60780 Poznan, Poland
关键词
rheumatoid arthritis; mesenchymal stromal cells; fibroblast-like synoviocytes; macrophages; inflammation; FIBROBLAST-LIKE SYNOVIOCYTES; COLLAGEN-INDUCED ARTHRITIS; UMBILICAL-CORD BLOOD; STEM-CELLS; BONE-MARROW; TNF-ALPHA; MACROPHAGE POLARIZATION; EXTRACELLULAR VESICLES; SYNOVIAL FIBROBLASTS; ADIPOSE-TISSUE;
D O I
10.3390/cells13110915
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterised by the formation of a hyperplastic pannus, as well as cartilage and bone damage. The pathogenesis of RA is complex and involves broad interactions between various cells present in the inflamed synovium, including fibroblast-like synoviocytes (FLSs), macrophages, and T cells, among others. Under inflammatory conditions, these cells are activated, further enhancing inflammatory responses and angiogenesis and promoting bone and cartilage degradation. Novel treatment methods for RA are greatly needed, and mesenchymal stromal cells (MSCs) have been suggested as a promising new regenerative and immunomodulatory treatment. In this paper, we present the interactions between MSCs and RA-FLSs, and macrophages and T cells, and summarise studies examining the use of MSCs in preclinical and clinical RA studies.
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页数:17
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