The roles of non-coding RNAs in Hirschsprung's disease

被引：1
作者：
Yang, Yang [1 ]
Hou, Xinwei [1 ]
Wang, Chen [1 ]
Chen, Qinming [1 ]
Lu, Yi [1 ]
Yu, Daiyue [1 ]
Wu, Kai [1 ]
机构：
[1] Southern Med Univ, Zhujiang Hosp, Dept Pediat Surg, Guangzhou 510282, Guangdong, Peoples R China
来源：
NON-CODING RNA RESEARCH | 2024年 / 9卷 / 03期
关键词：
Hirschsprung's disease; NcRNAs; MiRNAs; LncRNAs; CircRNAs; CELL-MIGRATION; DOWN-REGULATION; COLON SEGMENTS; ENDOGENOUS RNA; EXPRESSION; PROLIFERATION; PATHOGENESIS; GENE; MIRNAS; CANCER;
D O I：
10.1016/j.ncrna.2024.02.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hirschsprung's disease (HSCR) is a congenital disorder characterized by the absence of ganglion cells in the colon, leading to various intestinal complications. The etiology of HSCR stems from complex genetic and environmental interactions, of which the intricate roles of non -coding RNAs (ncRNAs) are a key area of research. However, the roles of ncRNAs in the pathogenesis of HSCR have not been fully elucidated. In order to understand the variety of symptoms caused by HSCR and develop new therapeutic approaches, it is essential to understand the underlying biological genetic basis of HSCR. This review presents a comprehensive overview of the current understanding regarding the involvement of ncRNAs in HSCR, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Additionally, it provides a summary of the molecular mechanisms through which ncRNAs regulate the expression of genes related to the proliferation, migration, and differentiation of intestinal neural crest cells, thereby contributing to the advancement of HSCR research.
引用
收藏
页码：704 / 714
页数：11
相关论文
共 118 条
[21]   Systematic screen of potential circular RNA biomarkers of Hirschsprung's disease [J].
Huang, Shun-Gen ;
Cheng, Yuan ;
Li, Dashuang ;
Sun, Chao ;
Fang, Fang ;
Guo, Wan-Liang .
TRANSLATIONAL PEDIATRICS, 2022, 11 (01) :10-19
[22]   Advances in esophageal cancer: A new perspective on pathogenesis associated with long non-coding RNAs [J].
Huang, Xiaomei ;
Zhou, Xi ;
Hu, Qing ;
Sun, Binyu ;
Deng, Mingming ;
Qi, Xiaolong ;
Lu, Muhan .
CANCER LETTERS, 2018, 413 :94-101
[23]   The m6A methyltransferase METTL3 affects cell proliferation and migration by regulating YAP expression in Hirschsprung disease [J].
Huang, Zhaorong ;
Luo, Caiyun ;
Hou, Xinwei ;
Yu, Daiyue ;
Su, Yuqian ;
Li, Xinxin ;
Luo, Yinyan ;
Liao, Guoying ;
Mu, Jianhua ;
Wu, Kai .
PEDIATRIC SURGERY INTERNATIONAL, 2023, 39 (01)
[24]   The relationship between prenatal exposure to BP-3 and Hirschsprung's disease [J].
Huo, Weiwei ;
Cai, Peng ;
Chen, Minjian ;
Li, Hongxing ;
Tang, Junwei ;
Xu, Chao ;
Zhu, Dongmei ;
Tang, Weibing ;
Xia, Yankai .
CHEMOSPHERE, 2016, 144 :1091-1097
[25]   The Functions of MicroRNAs: mRNA Decay and Translational Repression [J].
Iwakawa, Hiro-oki ;
Tomari, Yukihide .
TRENDS IN CELL BIOLOGY, 2015, 25 (11) :651-665
[26]   miR-92a represses the viability and migration of nerve cells in Hirschsprung's disease by regulating the KLF4/PI3K/AKT pathway [J].
Ji, Chun-Yi ;
Yuan, Miao-Xian ;
Chen, Li-Jian ;
Gao, Hong-Qiang ;
Zhang, Tian ;
Yin, Qiang .
ACTA NEUROBIOLOGIAE EXPERIMENTALIS, 2022, 82 (03) :336-346
[27]   The role of m6A modification in the biological functions and diseases [J].
Jiang, Xiulin ;
Liu, Baiyang ;
Nie, Zhi ;
Duan, Lincan ;
Xiong, Qiuxia ;
Jin, Zhixian ;
Yang, Cuiping ;
Chen, Yongbin .
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 6 (01)
[28]   Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA [J].
Kang, Min ;
Tang, Bo ;
Li, Jixi ;
Zhou, Ziyan ;
Liu, Kang ;
Wang, Rensheng ;
Jiang, Ziyan ;
Bi, Fangfang ;
Patrick, David ;
Kim, Dongin ;
Mitra, Anirban K. ;
Yang-Hartwich, Yang .
MOLECULAR CANCER, 2020, 19 (01)
[29]   Ablation of Ezh2 in neural crest cells leads to aberrant enteric nervous system development in mice [J].
Kim, Hana ;
Langohr, Ingeborg M. ;
Faisal, Mohammad ;
McNulty, Margaret ;
Thorn, Caitlin ;
Kim, Joomyeong .
PLOS ONE, 2018, 13 (08)
[30]   The emerging roles of circRNAs in cancer and oncology [J].
Kristensen, Lasse S. ;
Jakobsen, Theresa ;
Hager, Henrik ;
Kjems, Jorgen .
NATURE REVIEWS CLINICAL ONCOLOGY, 2022, 19 (03) :188-206
12345678910