Estrogen receptor beta expression and role in cancers

被引：5

作者：

Monteiro, Fatima L. ^{[1
,2
]}

Stepanauskaite, Lina ^{[1
,2
]}

Archer, Amena ^{[1
,2
]}

Williams, Cecilia ^{[1
,2
,3
]}

机构：

[1] KTH Royal Inst Technol, Dept Prot Sci, SciLifeLab, S-17121 Solna, Sweden

[2] Karolinska Inst, Dept Biosci & Nutr, S-14183 Huddinge, Sweden

[3] KTH Royal Inst Technol, Dept Prot Sci, Box 1031, S-17121 Solna, Sweden

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2024年 / 242卷

基金：

美国国家卫生研究院; 瑞典研究理事会;

关键词：

Estrogen receptor beta; ESR2; isoforms; expression; cancer; microenvironment; ER-BETA; CELL-LINE; LYMPHOMA GROWTH; ALPHA; AROMATASE; GENERATION; DIAGNOSIS; SEQUENCE; PROSTATE; CLONING;

D O I：

10.1016/j.jsbmb.2024.106526

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Estrogen drives the growth of some cancers, such as breast cancer, via estrogen receptor alpha (ER alpha). Estrogen also activates ER beta, but whether ER beta is expressed and has a role in different cancers is debated. The use of nonspecific antibodies has contributed to the confusion, and this review delves into ER beta's controversial role in cancer and focuses on tumor expression that can be supported by non-antibody-dependent assays. We discuss its expression at the transcript level and focus on its potential role in lymphoma, granulosa cell tumors, testicular, and adrenal cancers, emphasizing recent findings and the complexities that necessitate further research.

引用

页数：9

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