ACAT1 promotes proliferation and metastasis of bladder cancer via AKT/GSK3 β /c-Myc signaling pathway

被引：1

作者：

Wang, Tingjun ^{[1
]}

Wang, Gang ^{[1
,2
]}

Shan, Danni ^{[2
]}

Fang, Yayun ^{[2
]}

Zhou, Fenfang ^{[3
]}

Yu, Mengxue ^{[2
]}

Ju, Lingao ^{[2
]}

Li, Gang ^{[2
]}

Xiang, Wan ^{[2
]}

Qian, Kaiyu ^{[1
,2
]}

Zhang, Yi ^{[4
,5
]}

Xiao, Yu ^{[2
]}

Wang, Xinghuan ^{[1
,6
]}

机构：

[1] Wuhan Univ, Zhongnan Hosp, Dept Urol, Lab Precis Med, Wuhan, Peoples R China

[2] Wuhan Univ, Human Genet Resources Preservat Ctr Hubei Prov, Dept Biol Repositories, Hubei Key Lab Urol Dis,Zhongnan Hosp, Wuhan, Peoples R China

[3] Wuhan Univ, Zhongnan Hosp, Dept Radiol, Wuhan, Peoples R China

[4] ZGC Life Sci Pk, Euler Technol, Beijing, Peoples R China

[5] Peking Univ, Ctr Quantitat Biol, Sch Life Sci, Beijing, Peoples R China

[6] Wuhan Univ, Med Res Inst, Frontier Sci Ctr Immunol & Metab, Taikang Ctr Life & Med Sci, Wuhan, Peoples R China

来源：

JOURNAL OF CANCER | 2024年 / 15卷 / 11期

基金：

中国国家自然科学基金;

关键词：

bladder cancer; ACAT1; AKT/GSK3; beta/c-Myc; proliferation; metastasis; CISPLATIN-INELIGIBLE PATIENTS; UROTHELIAL CARCINOMA; SINGLE-ARM; MULTICENTER; DOXORUBICIN; ACTIVATION; EXPRESSION; CELLS; ATEZOLIZUMAB; METHOTREXATE;

D O I：

10.7150/jca.95549

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acetyl-CoA acetyltransferase 1 (ACAT1) plays a significant role in the regulation of gene expression and tumorigenesis. However, the biological role of ACAT1 in bladder cancer (BLCA) has yet to be elucidated. This research aimed to elucidate the bioinformatics features and biological functions of ACAT1 in BLCA. Here, we demonstrate that ACAT1 is elevated in BLCA tissues and is correlated with specific clinicopathological features and an unfavorable prognosis for survival in BLCA patients. ACAT1 was identified as an independent risk factor in BLCA. Phenotypically, both in vitro and in vivo , ACAT1 knockdown suppressed BLCA cell proliferation and migration, while ACAT1 overexpression had the opposite effect. Mechanistic assays revealed that ACAT1 enhances BLCA cell proliferation and metastasis through the AKT/GSK3 beta /c-Myc signaling pathway by modulating the cell cycle and EMT. Taken together, the results of our study reveal that ACAT1 is an oncogenic driver in BLCA that enhances tumor proliferation and metastasis, indicating its potential as a diagnostic and therapeutic target for this disease.

引用

页码：3297 / 3312

页数：16

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