Consistency of the maximum likelihood estimator of population tree in a coalescent framework

被引:0
作者
Choudhury, Arindam Roy [1 ]
机构
[1] Cornell Univ, Dept Populat Hlth Sci, Div Biostat, Weill Cornell Med, New York, NY 14850 USA
基金
美国国家科学基金会;
关键词
Population tree; Phylogenetic tree; Maximum likelihood; Consistency; Coalescent; PHYLOGENETIC TREES; PRUNING ALGORITHM; IDENTIFIABILITY; MODELS;
D O I
10.1016/j.jspi.2024.106172
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
We present a proof of consistency of the maximum likelihood estimator (MLE) of population tree in a previously proposed coalescent model. As the model involves tree -topology as a parameter, the standard proof of consistency for continuous parameters does not directly apply. In addition to proving that a consistent sequence of MLE exists, we also prove that the overall MLE, computed by maximizing the likelihood over all tree -topologies, is also consistent. Thus, the MLE of tree -topology is consistent as well. The last result is important because local maxima occur in the likelihood of population trees, especially while maximizing the likelihood separately for each tree -topology. Even though MLE is known to be a dependable estimator under this model, our work proves its effectiveness with mathematical certainty.
引用
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页数:10
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