Recent Advances and Outlook of Benzopyran Derivatives in the Discovery of Agricultural Chemicals

被引:3
作者
Liu, Xing [1 ]
Zhang, Yong [1 ]
Zou, Yue [1 ]
Yan, Chongchong [1 ]
Chen, Jixiang [1 ]
机构
[1] Guizhou Univ, Ctr R & D Fine Chem, Minist Educ, State Key Lab Green Pesticide,Key Lab Green Pestic, Guiyang 550025, Peoples R China
关键词
benzopyran; agricultural chemicals; activefragments; SAR; mechanism; HERBICIDAL ACTIVITY; BIOLOGICAL EVALUATION; COUMARIN DERIVATIVES; NEMATOCIDAL ACTIVITY; ANTIFUNGAL ACTIVITY; FLAVONOIDS; DESIGN; IDENTIFICATION; ANTIBACTERIAL; MECHANISM;
D O I
10.1021/acs.jafc.3c09244
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Scaffold structures, new mechanisms of action, and targets present enormous challenges in the discovery of novel pesticides. The discovery of new scaffolds is the basis for the continuous development of modern agrochemicals. Identification of a good scaffold such as triazole, carbamate, methoxy acrylate, pyrazolamide, pyrido-pyrimidinone mesoionic, and bisamide often leads to the development of a new series of pesticides. In addition, pesticides with the same target, including the inhibitors of succinate dehydrogenase (SDH), oxysterol-binding-protein, and p-hydroxyphenyl pyruvate dioxygenase (HPPD), may have the same or similar scaffold structure. Recent years have witnessed significant progress in the discovery of new pesticides using natural products as scaffolds or bridges. In recent years, there have been increasing reports on the application of natural benzopyran compounds in the discovery of new pesticides, especially osthole and coumarin. A systematic and comprehensive review of benzopyran active compounds in the discovery of new agricultural chemicals is helpful to promote the discussion and development of benzopyran active compounds. Therefore, this work systematically reviewed the research and application of benzopyran derivatives in the discovery of agricultural chemicals, summarized the antiviral, herbicidal, antibacterial, fungicidal, insecticidal, nematicidal and acaricidal activities of benzopyran active compounds, and discussed the structural-activity relationship and mechanism of action. In addition, some active fragments were recommended to further optimize the chemical structure of benzopyran active compounds based on reference information.
引用
收藏
页码:12300 / 12318
页数:19
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