Developmental toxicity and mechanism of dibutyl phthalate and alternative diisobutyl phthalate in the early life stages of zebrafish (Danio rerio)
被引:3
作者:
Tao, Huan-Yu
论文数: 0引用数: 0
h-index: 0
机构:
Southern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
Univ Hong Kong, Environm Engn Res Ctr, Dept Civil Engn, Hong Kong, Peoples R ChinaSouthern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
Tao, Huan-Yu
[1
,2
]
Shi, Jianghong
论文数: 0引用数: 0
h-index: 0
机构:
Southern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R ChinaSouthern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
Shi, Jianghong
[1
]
Zhang, Jiawei
论文数: 0引用数: 0
h-index: 0
机构:
Southern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
Univ Hong Kong, Environm Engn Res Ctr, Dept Civil Engn, Hong Kong, Peoples R ChinaSouthern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
Zhang, Jiawei
[1
,2
]
Ge, Hui
论文数: 0引用数: 0
h-index: 0
机构:
Southern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R ChinaSouthern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
Ge, Hui
[1
]
Zhang, Mengtao
论文数: 0引用数: 0
h-index: 0
机构:
Tsinghua Univ, Grad Sch Shenzhen, Key Lab Microorganism Applicat & Risk Control Shen, Shenzhen 518055, Peoples R ChinaSouthern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
Zhang, Mengtao
[3
]
Li, Xiao-Yan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hong Kong, Environm Engn Res Ctr, Dept Civil Engn, Hong Kong, Peoples R China
Tsinghua Univ, Grad Sch Shenzhen, Key Lab Microorganism Applicat & Risk Control Shen, Shenzhen 518055, Peoples R ChinaSouthern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
Li, Xiao-Yan
[2
,3
]
机构:
[1] Southern Univ Sci & Technol, Sch Environm Sci & Engn, Shenzhen 518055, Peoples R China
[2] Univ Hong Kong, Environm Engn Res Ctr, Dept Civil Engn, Hong Kong, Peoples R China
[3] Tsinghua Univ, Grad Sch Shenzhen, Key Lab Microorganism Applicat & Risk Control Shen, Shenzhen 518055, Peoples R China
Diisobutyl phthalate (DiBP), is widely chemical replacement for Dibutyl phthalate (DBP). Although DBP and DiBP have been detected in surface water worldwide, few studies to date have systematically assessed the risks of DBP and its alternatives to aquatic organisms. The present study compared DBP and DiBP for their individual and joint toxicity as well as thyroid hormone levels in zebrafish embryo. Transcripts of key genes related to the hypothalamic-pituitary-thyroid (HPT) axis were investigated in developing zebrafish larvae by application of real time polymerase chain reaction. The median half-lethal concentrations of DBP and DiBP to zebrafish at 96 h were 0.545 mg L-1 and 1.149 mg L-1, respectively. The joint toxic effect of DBP-DiBP (0.25-0.53 mg L-1) with the same ratio showed a synergistic effect. Thyroid hormones levels increased with exposure to 10 mu g L-1 of DBP or 50 mu g L-1 of DiBP, and exposure to both compounds significantly increased thyroid gland-specific transcription of thyroglobulin gene (tg), hyronine deiodinase (dio2), and transthyretin (ttr), indicating an adverse effect associated with the HPT axis. Molecular docking results indicated that DBP (-7.10 kcal/M and -7.53 kcal/M) and DiBP (-6.63 kcal/M and -7.42 kcal/M) had the same docking energy with thyroid hormone receptors. Our data facilities an understand of potential harmful effects of DBP and its alternative (DiBP).
机构:
Vitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Chen, Xueping
;
Xu, Shisan
论文数: 0引用数: 0
h-index: 0
机构:
City Univ Hong Kong, Dept Biol & Chem, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Xu, Shisan
;
Tan, Tianfeng
论文数: 0引用数: 0
h-index: 0
机构:
Vitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Tan, Tianfeng
;
Lee, Sin Ting
论文数: 0引用数: 0
h-index: 0
机构:
Vitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Lee, Sin Ting
;
Cheng, Shuk Han
论文数: 0引用数: 0
h-index: 0
机构:
City Univ Hong Kong, Dept Biol & Chem, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Cheng, Shuk Han
;
Lee, Fred Wang Fat
论文数: 0引用数: 0
h-index: 0
机构:
Open Univ Hong Kong, Sch Sci & Technol, Kowloon, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Lee, Fred Wang Fat
;
Xu, Steven Jing Liang
论文数: 0引用数: 0
h-index: 0
机构:
Open Univ Hong Kong, Sch Sci & Technol, Kowloon, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Xu, Steven Jing Liang
;
Ho, Kin Chung
论文数: 0引用数: 0
h-index: 0
机构:
Open Univ Hong Kong, Sch Sci & Technol, Kowloon, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
机构:
Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R ChinaHarbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R China
Gao, Dawen
;
Li, Zhe
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R ChinaHarbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R China
Li, Zhe
;
Wang, He
论文数: 0引用数: 0
h-index: 0
机构:
Northeast Forestry Univ, Coll Wildlife Resources, Harbin 150040, Heilongjiang, Peoples R ChinaHarbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R China
Wang, He
;
Liang, Hong
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R ChinaHarbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R China
机构:
Vitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Chen, Xueping
;
Xu, Shisan
论文数: 0引用数: 0
h-index: 0
机构:
City Univ Hong Kong, Dept Biol & Chem, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Xu, Shisan
;
Tan, Tianfeng
论文数: 0引用数: 0
h-index: 0
机构:
Vitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Tan, Tianfeng
;
Lee, Sin Ting
论文数: 0引用数: 0
h-index: 0
机构:
Vitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Lee, Sin Ting
;
Cheng, Shuk Han
论文数: 0引用数: 0
h-index: 0
机构:
City Univ Hong Kong, Dept Biol & Chem, State Key Lab Marine Pollut, Kowloon, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Cheng, Shuk Han
;
Lee, Fred Wang Fat
论文数: 0引用数: 0
h-index: 0
机构:
Open Univ Hong Kong, Sch Sci & Technol, Kowloon, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Lee, Fred Wang Fat
;
Xu, Steven Jing Liang
论文数: 0引用数: 0
h-index: 0
机构:
Open Univ Hong Kong, Sch Sci & Technol, Kowloon, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
Xu, Steven Jing Liang
;
Ho, Kin Chung
论文数: 0引用数: 0
h-index: 0
机构:
Open Univ Hong Kong, Sch Sci & Technol, Kowloon, Hong Kong, Peoples R ChinaVitargent Int Biotechnol Ltd, Shatin, Hong Kong, Peoples R China
机构:
Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R ChinaHarbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R China
Gao, Dawen
;
Li, Zhe
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R ChinaHarbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R China
Li, Zhe
;
Wang, He
论文数: 0引用数: 0
h-index: 0
机构:
Northeast Forestry Univ, Coll Wildlife Resources, Harbin 150040, Heilongjiang, Peoples R ChinaHarbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R China
Wang, He
;
Liang, Hong
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R ChinaHarbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R China