Complete hematologic response in a patient with multiple pretreated angioimmunoblastic T-cell lymphoma after belinostat therapy followed by allogeneic stem cell transplantation: A case report

被引：0

作者：

De Wilde, Sigrid ^{[1
]}

Graux, Carlos ^{[2
]}

机构：

[1] Ctr Hosp Luxembourg, 4 Rue Nicolas Ernest Barble, L-1210 Luxembourg, Luxembourg

[2] CHU UCL, Namur, Belgium

来源：

CLINICAL CASE REPORTS | 2024年 / 12卷 / 07期

关键词：

allogenic stem cell transplantation; belinostat; HDAC inhibitor; nTFHL-AI; PTCL; HEALTH-ORGANIZATION CLASSIFICATION; BRENTUXIMAB-VEDOTIN; RARE;

D O I：

10.1002/ccr3.9159

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Key Clinical MessageBelinostat therapy followed by hematopoietic stem cell transplantation is a promising salvage strategy for heavily pretreated patients with peripheral T-cell lymphoma.AbstractEffective treatments for peripheral T-cell lymphoma in the relapsed and refractory (r/r) setting are limited. However, with the development and approval of innovative therapies, effective therapeutic options are becoming available for this patient population. This case report describes the treatment course of a patient with multiple r/r nodal follicular T-helper cell lymphoma of angioimmunoblastic type. Treatment with the histone deacetylase inhibitor belinostat as bridging, enabled allogeneic stem cell transplantation and resulted in a durable complete hematologic response for at least 21 months post-transplantation.

引用

页数：8

共 32 条

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