Facile construction of benzofulvene frameworks via a palladium-catalysed three-component reaction

被引：0
|
作者：
Zhu, Bo [1 ,2 ]
Chen, Zhi-Chao [1 ,2 ]
Du, Wei [1 ,2 ]
Chen, Ying-Chun [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Chengdu 610041, Peoples R China
[3] Third Mil Med Univ, Coll Pharm, Chongqing 400038, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 42期
基金：
中国国家自然科学基金;
关键词：
BIOLOGICAL EVALUATION; INHIBITORS; LIGANDS; 1,3-ENYNES; 1,3-DIENES; ANNULATION; SULINDAC;
D O I：
10.1039/d4ob01414f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Here we report a three-component reaction of 2-formylarylboronic acids, N-sulfonyl amines and 1,3-enynes, proceeding through a cascade imine formation/Pd-0-catalysed vinylogous addition/intramolecular Suzuki coupling/isomerization process. This protocol exhibited broad substrate scope and good functionality tolerance, and a spectrum of multifunctionalised benzofulvene derivatives were furnished in moderate to good yields and E/Z-selectivity.
引用
收藏
页码：8397 / 8400
页数：4
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