AI-driven Q-learning for personalized acne genetics: Innovative approaches and potential genetic markers

被引:0
|
作者
Chua, Yong Chi [1 ]
Nies, Hui Wen [1 ]
Kamsani, Izyan Izzati [1 ]
Hashim, Haslina [1 ]
Yusoff, Yusliza [1 ]
Chan, Weng Howe [1 ]
Remli, Muhammad Akmal [2 ]
Nies, Yong Hui [3 ]
Mohamad, Mohd Saberi [4 ]
机构
[1] Univ Teknol Malaysia, Fac Comp, Johor Baharu 81310, Malaysia
[2] Univ Malaysia Kelantan, Inst Artificial Intelligence & Big Data, Kota Baharu 16100, Malaysia
[3] Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Med Ctr, Kuala Lumpur 56000, Malaysia
[4] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Genet & Genom, Hlth Data Sci Lab, Al Ain 15551, U Arab Emirates
关键词
Q-learning; Genetic marker selection; Acne genetics; Reinforcement learning; Gene expression data; PubMed text data mining; VULGARIS; CHINESE;
D O I
10.1016/j.eij.2024.100484
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Genetic markers for acne are being studied to create personalized treatments based on an individual 's genes, and the field is benefiting from the application of artificial intelligence (AI) techniques. One such AI tool, the Qlearning algorithm, is increasingly being utilized by medical researchers to delve into the genetics of acne. In contrast to previous methods, our research introduces a Q -learning model that is adaptable to diverse sample groups. This innovative approach involves preprocessing data by identifying differentially expressed genes and constructing gene -gene connectivity networks. The key advantage of using the Q -learning model lies in its ability to transform acne gene data into Markovian domains, which are essential for selecting relevant genetic markers. Performance evaluations of our Q -learning model have shown high accuracy and specificity, although there may be some sensitivity variations. Notably, this research has identified specific genes, such as CD86, AGPAT3, TMPRSS11D, DSG3, TNFRSF1B, PI3, C5AR1, and KRT16, as being acne -related through biological verification and text data mining. These findings underscore the potential of AI -driven Q -learning models to revolutionize the study of acne genetics. In conclusion, our Q -learning model offers a promising approach for the selection of acnerelated genetic markers, despite minor sensitivity fluctuations. This research highlights the transformative potential of Q -learning in advancing our understanding of the genetics underlying acne, paving the way for more personalized and effective treatments in the future.
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页数:10
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