Modeling drug transport and absorption in subcutaneous injection of monoclonal antibodies: Impact of tissue deformation, devices, and physiology

被引:1
作者
de Lucio, Mario [1 ]
Leng, Yu [2 ]
Wang, Hao [1 ]
Vlachos, Pavlos P. [1 ]
Gomez, Hector [1 ]
机构
[1] Purdue Univ, Sch Mech Engn, 585 Purdue Mall, W Lafayette, IN 47907 USA
[2] Los Alamos Natl Lab, Los Alamos, NM 87544 USA
基金
美国国家科学基金会;
关键词
Subcutaneous injection; Poroelasticity; Auto-injector; Drug transport; Lymphatic uptake; INTERSTITIAL FLUID-FLOW; FIELD BULGE TEST; LYMPHATIC FUNCTION; DEPOT CLEARANCE; ADIPOSE-TISSUE; NEEDLE LENGTH; PRESSURE; SKIN; QUANTIFICATION; SIMULATION;
D O I
10.1016/j.ijpharm.2024.124446
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The pharmaceutical industry has experienced a remarkable increase in the use of subcutaneous injection of monoclonal antibodies (mAbs), attributed mainly to its advantages in reducing healthcare-related costs and enhancing patient compliance. Despite this growth, there is a limited understanding of how tissue mechanics, physiological parameters, and different injection devices and techniques influence the transport and absorption of the drug. In this work, we propose a high-fidelity computational model to study drug transport and absorption during and after subcutaneous injection of mAbs. Our numerical model includes large-deformation mechanics, fluid flow, drug transport, and blood and lymphatic uptake. Through this computational framework, we analyze the tissue material responses, plume dynamics, and drug absorption. We analyze different devices, injection techniques, and physiological parameters such as BMI, flow rate, and injection depth. Finally, we compare our numerical results against the experimental data from the literature.
引用
收藏
页数:17
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