Apolipoprotein C-III, familial chylomicronemia syndrome, and olezarsen

被引：2

作者：

Valdivielso, Pedro ^{[1
]}

Prieto, Inmaculada Coca ^{[1
]}

机构：

[1] Univ Malaga, Hosp Univ Virgen Victoria, Dept Med & Dermatologia, Serv Med Interna,Lipid Unit,Inst Deinvest Biomed I, Malaga, Spain

来源：

MED | 2024年 / 5卷 / 06期

关键词：

D O I：

10.1016/j.medj.2024.05.004

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Reducing the synthesis of apoC-III reduces fasting triglycerides in individuals lacking lipoprotein lipase activity. Recently, Stroes et al. 1 published a phase 3 trial on the effects of olezarsen, a third-generation antisense oligonucleotide that blocks apoC-III mRNA, on triglycerides and risk of acute pancreatitis.

引用

页码：493 / 494

页数：2

共 10 条

[1]

Cefalu A., 2022, J CLIN LIPIDOL, V16, pe17, DOI [10.1016/j. jacl.2021.09.024, DOI 10.1016/J.JACL.2021.09.024]

[2] Efficacy and Safety of Volanesorsen (ISIS 304801): the Evidence from Phase 2 and 3 Clinical Trials [J].

Fogacci, Federica ;

Norata, Giuseppe Danilo ;

Toth, Peter P. ;

Arca, Marcello ;

Cicero, Arrigo F. G. .

CURRENT ATHEROSCLEROSIS REPORTS, 2020, 22 (05)

[3] Molecular basis of the familial chylomicronemia syndrome in patients from the National Dyslipidemia Registry of the Spanish Atherosclerosis Society [J].

Jose Ariza, Maria ;

Rioja, Jose ;

Ibarretxe, Daiana ;

Camacho, Ana ;

Luis Diaz-Diaz, Jose ;

Mangas, Alipio ;

Carbayo-Herencia, Julio A. ;

Ruiz-Ocana, Pablo ;

Lamiquiz-Moneo, Itziar ;

Mosquera, Daniel ;

Saenz, Pedro ;

Masana, Luis ;

Muniz-Grijalvo, Ovidio ;

Perez-Calahorra, Sofia ;

Valdivielso, Pedro .

JOURNAL OF CLINICAL LIPIDOLOGY, 2018, 12 (06) :1482-1492

[4] Clinical review on triglycerides [J].

Laufs, Ulrich ;

Parhofer, Klaus G. ;

Ginsberg, Henry N. ;

Hegele, Robert A. .

EUROPEAN HEART JOURNAL, 2020, 41 (01) :99-+

[5]

Ministerio de Sanidad Profesionales, SISTEMA INFORMACION

[6] Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial [J].

Rosenson, Robert S. ;

Gaudet, Daniel ;

Ballantyne, Christie M. ;

Baum, Seth J. ;

Bergeron, Jean ;

Kershaw, Erin E. ;

Moriarty, Patrick M. ;

Rubba, Paolo ;

Whitcomb, David C. ;

Banerjee, Poulabi ;

Gewitz, Andrew ;

Gonzaga-Jauregui, Claudia ;

McGinniss, Jennifer ;

Ponda, Manish P. ;

Pordy, Robert ;

Zhao, Jian ;

Rader, Daniel J. .

NATURE MEDICINE, 2023, 29 (03) :729-+

[7] The association of triglyceride levels with the incidence of initial and recurrent acute pancreatitis [J].

Sanchez, Robert J. ;

Ge, Wenzhen ;

Wei, Wenhui ;

Ponda, Manish P. ;

Rosenson, Robert S. .

LIPIDS IN HEALTH AND DISEASE, 2021, 20 (01)

[8] Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome [J].

Stroes, Erik S. G. ;

Alexander, Veronica J. ;

Karwatowska-Prokopczuk, Ewa ;

Hegele, Robert A. ;

Arca, Marcello ;

Ballantyne, Christie M. ;

Soran, Handrean ;

Prohaska, Thomas A. ;

Xia, Shuting ;

Ginsberg, Henry N. ;

Witztum, Joseph L. ;

Tsimikas, Sotirios .

NEW ENGLAND JOURNAL OF MEDICINE, 2024, 390 (19) :1781-1792

[9] Symptoms and impacts of familial chylomicronemia syndrome: a qualitative study of the patient experience [J].

Williams, Kate ;

Tickler, Georgina ;

Valdivielso, Pedro ;

Alonso, Jordi ;

Vera-Llonch, Montserrat ;

Cubells, Laia ;

Acaster, Sarah .

ORPHANET JOURNAL OF RARE DISEASES, 2023, 18 (01)

[10] Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome [J].

Witztum, J. L. ;

Gaudet, D. ;

Freedman, S. D. ;

Alexander, V. J. ;

Digenio, A. ;

Williams, K. R. ;

Yang, Q. ;

Hughes, S. G. ;

Geary, R. S. ;

Arca, M. ;

Stroes, E. S. G. ;

Bergeron, J. ;

Soran, H. ;

Civeira, F. ;

Hemphill, L. ;

Tsimikas, S. ;

Blom, D. J. ;

O'Dea, L. ;

Bruckert, E. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (06) :531-542

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