Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio

The current study was planned to compare serum levels of secreted frizzled related protein -4, insulin resistance and waist -to -height ratio in individuals with and without a diabetic background, and to assess the correlation of these markers with family history of diabetes. The cross-sectional comparative study comprised 80 subjects with confirmed normal glucose tolerance values. Parameters assessed included secreted frizzled related protein -4, fasting glucose, random glucose, fasting insulin, homeostasis model of assessment of insulin resistance and waist -toheight ratio values. Those without a diabetic background had significantly higher frizzled related protein -4 levels ( p=0.02). Although subjects with family history of diabetes showed higher mean fasting glucose, waist circumference and waist -to -height ratio, these differences were not statistically significant ( p>0.05). However, there was a strong positive correlation with waist circumference, waistto -height ratio, fasting insulin and homeostasis model of assessment of insulin resistance ( p=0.0001). There was no significant correlation of diabetic background with frizzled related protein -4 SFRP-4, homeostasis model of assessment of insulin resistance and waist -to -height ratio ( p>0.05).