Experimental and numerical characterization of screw elements used in twin-screw extrusion

被引:4
作者
Duephans, Vanessa [1 ]
Kimmel, Vincent [1 ]
Messing, Lukas [1 ]
Schaldach, Gerhard [1 ]
Thommes, Markus [1 ]
机构
[1] TU Dortmund Univ, Dept Biochem & Chem Engn, Lab Solids Proc Engn, Emil Figge Str 68, D-44227 Dortmund, Germany
关键词
Extrusion; modeling; viscosity; screw; experiments; computational fluid dynamics; HOT-MELT EXTRUSION; FLOW; SIMULATION;
D O I
10.1080/10837450.2024.2378323
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Hot melt extrusion by a co-rotating twin screw extruder is an important process in the pharmaceutical industry. Especially for quality by design aspects, a comprehensive process understanding is indispensable. The performance of conveying elements was determined as critical process parameter, and therefore an experimental and numerical framework was developed to analyze and compare variations. A test rig capable of measuring volume flow, pressure and torque with high accuracy and precision was designed and built. The 3D simulation was performed using computational fluid dynamics (CFD). A stationary model with impulse transmission and an apparent motion of the screws was applied. The experimental data were fitted to the model of Pawlowski, and parameters for the pressure (A(1), A(2)) and power characteristics (B-1, B-2) were determined. Good agreement between experimental data and the model was observed. The simulation was significantly faster compared to common methods, and the results were consistent with the literature. Systematic investigations of a native and worn screw were performed with CFD resulting in a transport capacity increase and a pressure build up decrease for all tested screw elements. An experimental and simulation setup was generated to assess the performance of co-rotating twin screw elements. The experiments provided high-quality data, and the simulations exhibited high flexibility with low computational effort.
引用
收藏
页码:675 / 683
页数:9
相关论文
共 45 条
[1]   A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions: Theoretical prediction to practical implementation [J].
Alzahrani, Abdullah ;
Nyavanandi, Dinesh ;
Mandati, Preethi ;
Youssef, Ahmed Adel Ali ;
Narala, Sagar ;
Bandari, Suresh ;
Repka, Michael .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 624
[2]   Characteristic parameters and process maps for fully-filled twin-screw extruder elements [J].
Bauer, Hannes ;
Matic, Josip ;
Khinast, Johannes .
CHEMICAL ENGINEERING SCIENCE, 2021, 230
[3]   Three-dimensional modelling of flow curves in co-rotating twin-screw extruder elements [J].
Bayyeya, M. A. ;
Vega, J. F. ;
Martfnez-Salazar, J. .
JOURNAL OF MATERIALS PROCESSING TECHNOLOGY, 2008, 197 (1-3) :221-224
[4]  
Bierdel M., 2008, COROTATING TWIN SCRE, P139
[5]   Variational and momentum preservation aspects of Smooth Particle Hydrodynamic formulations [J].
Bonet, J ;
Lok, TSL .
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, 1999, 180 (1-2) :97-115
[6]   Numerical simulation of pressure and velocity profiles in kneading elements of a co-rotating twin screw extruder [J].
Bravo, VL ;
Hrymak, AN ;
Wright, JD .
POLYMER ENGINEERING AND SCIENCE, 2000, 40 (02) :525-541
[7]   Hot-melt extruded hydroxypropyl methylcellulose acetate succinate based amorphous solid dispersions: Impact of polymeric combinations on supersaturation kinetics and dissolution performance [J].
Butreddy, Arun ;
Sarabu, Sandeep ;
Almutairi, Mashan ;
Ajjarapu, Srinivas ;
Kolimi, Praveen ;
Bandari, Suresh ;
Repka, Michael A. .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2022, 615
[8]   Pharmaceutical applications of hot-melt extrusion: Part I [J].
Crowley, Michael M. ;
Zhang, Feng ;
Repka, Michael A. ;
Thumma, Sridhar ;
Upadhye, Sampada B. ;
Battu, Sunil Kumar ;
McGinity, James W. ;
Martin, Charles .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2007, 33 (09) :909-926
[9]   Simulation of flow and mixing for highly viscous fluid in a twin screw extruder with a conveying element using parallelized smoothed particle hydrodynamics [J].
Dong, Tianwen ;
Jiang, Shunliang ;
Wu, Jianchun ;
Liu, Hesheng ;
He, Yadong .
CHEMICAL ENGINEERING SCIENCE, 2020, 212
[10]   Comparison between 1D and 3D Approaches for Twin-Screw Extrusion Simulation [J].
Durin, A. ;
De Micheli, P. ;
Nguyen, H. -C. ;
David, C. ;
Valette, R. ;
Vergnes, B. .
INTERNATIONAL POLYMER PROCESSING, 2014, 29 (05) :641-648