New Therapeutic Horizons for Advanced or Metastatic Penile Cancer

被引：2

作者：

Simon, Nicholas ^{[1
]}

Atiq, Saad ^{[2
]}

Sonpavde, Guru ^{[3
]}

Apolo, Andrea ^{[4
]}

机构：

[1] NCI, Dept Oncol, Genitourinary Malignancies Branch, Ctr Canc Res,NIH, 10 Ctr Dr Bldg 10,Room 12C432B, Bethesda, MD 20892 USA

[2] NCI, Dept Oncol, Genitourinary Malignancies Branch, Ctr Canc Res,Magnuson Clin Ctr,NIH, Room B2L312, Bethesda, MD 20892 USA

[3] Univ Cent Florida, AdventHealth Canc Inst, Dept Urol, 2501 North Orange Ave, Orlando, FL 32804 USA

[4] NCI, Dept Oncol, Genitourinary Malignancies Branch, Ctr Canc Res,Magnuson Clin Ctr,NIH, Room 13N240, Bethesda, MD 20892 USA

来源：

UROLOGIC CLINICS OF NORTH AMERICA | 2024年 / 51卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Penile cancer; Immunotherapy; Targeted therapy; HPV; SQUAMOUS-CELL CARCINOMA; NEOADJUVANT CHEMOTHERAPY; CISPLATIN; EGFR; COMBINATION; EXPRESSION; PACLITAXEL; NIVOLUMAB; PD-L1;

D O I：

10.1016/j.ucl.2024.03.005

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

center dot Locally advanced or metastatic penile cancer has a poor prognosis with few therapeutic options. center dot Immune checkpoint inhibitors have demonstrated some efficacy, although response rates are low, prompting interest in combination strategies. center dot Human papillomavirus (HPV)-directed therapies are a significant area of interest, with many center dot Studies in adoptive T-cell therapies, including T-cell receptor therapy and tumor-infiltrating lymphocyte therapy, have shown early promise. center dot Penile cancer cells express cell surface markers that may be targeted by currently approved

引用

页码：367 / 376

页数：10

共 72 条

[1] CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn [J].

Albelda, Steven M. .

NATURE REVIEWS CLINICAL ONCOLOGY, 2024, 21 (01) :47-66

[2] Comprehensive Genomic Profiling of Advanced Penile Carcinoma Suggests a High Frequency of Clinically Relevant Genomic Alterations [J].

Ali, Siraj M. ;

Pal, Sumanta K. ;

Wang, Kai ;

Palma, Norma A. ;

Sanford, Eric ;

Bailey, Amark ;

He, Jie ;

Elvin, Julia A. ;

Chmielecki, Juliann ;

Squillace, Rachel ;

Dow, Edward ;

Morosini, Deborah ;

Buell, Jamie ;

Yelensky, Roman ;

Lipson, Doron ;

Frampton, Garrett M. ;

Howley, Peter ;

Ross, Jeffrey S. ;

Stephens, Philip J. ;

Miller, Vincent A. .

ONCOLOGIST, 2016, 21 (01) :33-39

[3] Phase I Study of Cabozantinib and Nivolumab Alone or With Ipilimumab for Advanced or Metastatic Urothelial Carcinoma and Other Genitourinary Tumors [J].

Apolo, Andrea B. ;

Nadal, Rosa ;

Girardi, Daniel M. ;

Niglio, Scot A. ;

Ley, Lisa ;

Cordes, Lisa M. ;

Steinberg, Seth M. ;

Sierra Ortiz, Olena ;

Cadena, Jacqueline ;

Diaz, Carlos ;

Mallek, Marissa ;

Davarpanah, Nicole N. ;

Costello, Rene ;

Trepel, Jane B. ;

Lee, Min-Jung ;

Merino, Maria J. ;

Bagheri, Mohammad Hadi ;

Monk, Paul ;

Figg, William D. ;

Gulley, James L. ;

Agarwal, Piyush K. ;

Valera, Vladimir ;

Chalfin, Heather J. ;

Jones, Jennifer ;

Streicher, Howard ;

Wright, John J. ;

Ning, Yangmin M. ;

Parnes, Howard L. ;

Dahut, William L. ;

Bottaro, Donald P. ;

Lara, Primo N., Jr. ;

Saraiya, Biren ;

Pal, Sumanta K. ;

Stein, Mark N. ;

Mortazavi, Amir .

JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (31) :3672-+

[4] Expansion of tumor-infiltrating lymphocytes (TIL) from penile cancer patients [J].

Aydin, Ahmet Murat ;

Hall, MacLean ;

Bunch, Brittany L. ;

Branthoover, Holly ;

Sannasardo, Zachary ;

Mackay, Amy ;

Beatty, Matthew ;

Sarnaik, Amod A. ;

Mullinax, John E. ;

Spiess, Philippe E. ;

Pilon-Thomas, Shari .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 94

[5] Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer [J].

Bardia, A. ;

Hurvitz, S. A. ;

Tolaney, S. M. ;

Loirat, D. ;

Punie, K. ;

Oliveira, M. ;

Brufsky, A. ;

Sardesai, S. D. ;

Kalinsky, K. ;

Zelnak, A. B. ;

Weaver, R. ;

Traina, T. ;

Dalenc, F. ;

Aftimos, P. ;

Lynce, F. ;

Diab, S. ;

Cortes, J. ;

O'Shaughnessy, J. ;

Dieras, V ;

Ferrario, C. ;

Schmid, P. ;

Carey, L. A. ;

Gianni, L. ;

Piccart, M. J. ;

Loibl, S. ;

Goldenberg, D. M. ;

Hong, Q. ;

Olivo, M. S. ;

Itri, L. M. ;

Rugo, H. S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (16) :1529-1541

[6]

Bear Adham S, 2021, Am Soc Clin Oncol Educ Book, V41, P57, DOI 10.1200/EDBK_321115

[7] Neoadjuvant chemotherapy followed by aggressive surgical consolidation for metastatic penile squamous cell carcinoma [J].

Bermejo, Carlos ;

Busby, J. Erik ;

Spiess, Philippe E. ;

Heller, Lior ;

Pagliaro, Lance C. ;

Pettaway, Curtis A. .

JOURNAL OF UROLOGY, 2007, 177 (04) :1335-1338

[8] European Association of Urology-American Society of Clinical Oncology Collaborative Guideline on Penile Cancer: 2023 Update [J].

Brouwer, Oscar R. ;

Albersen, Maarten ;

Parnham, Arie ;

Protzel, Chris ;

Pettaway, Curtis A. ;

Ayres, Benjamin ;

Antunes-Lopes, Tiago ;

Barreto, Lenka ;

Campi, Riccardo ;

Crook, Juanita ;

Fernandez-Pello, Sergio ;

Greco, Isabella ;

van der Heijden, Michiel S. ;

Johnstone, Peter A. S. ;

Kailavasan, Mithun ;

Manzie, Kenneth ;

Marcus, Jack David ;

Necchi, Andrea ;

Oliveira, Pedro ;

Osborne, John ;

Pagliaro, Lance C. ;

Garcia-Perdomo, Herney A. ;

Rumble, R. Bryan ;

Sachdeva, Ashwin ;

Sakalis, Vasileios I. ;

Zapala, Lukasz ;

Sanchez Martinez, Diego F. ;

Spiess, Philippe E. ;

Tagawa, Scott T. .

EUROPEAN UROLOGY, 2023, 83 (06) :548-560

[9] The International Penile Advanced Cancer Trial (InPACT): Rationale and Current Status [J].

Canter, Daniel J. ;

Nicholson, Steve ;

Watkin, Nick ;

Hall, Emma ;

Pettaway, Curtis .

EUROPEAN UROLOGY FOCUS, 2019, 5 (05) :706-709

[10] An update on treatment of penile cancer [J].

Chadha, Juskaran ;

Chahoud, Jad ;

Spiess, Philippe E. .

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2022, 14

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