IS SARM - Selective Androgen Receptor Modulator: A Chance for Therapeutic Approach in Muscle-Wasting Chronic Conditions?

Purpose of review. The purpose of this paper is to review the current concepts regarding a new-old pharmacological class, SARM (Selective Androgen Receptor Modulator). Especially how SARM can be beneficial in treatment of orthopedic disease. Materials and methods. Androgens (testosterone and dihydrotestosterone (DHT)) are the male sex hormones required for development of the male reproductive system and secondary sexual characteristics. SARMs due to ability to bind androgen receptor are excellent in treatment of various diseases. Discussion. Based on the published literature, a review has been carried out on SARM and its fields of application in the treatment of muscle wasting pathologies. Starting from the history of the SARMs, its role in prevention of muscle wasting, anabolic effects and side effects were addressed. Conclusions. Nonsteroidal SARMs are unique in their ability to bind the androgen receptor with high affinity and exhibit tissue selective activity. SARMs can be used to treat muscle wasting conditions, osteoporosis, frailty syndrome without unwanted side effects associated with androgens.