Novel metabolic biomarkers for the diagnosis of acute ischemic stroke

被引：1

作者：

Tang, Zhenzhen ^{[1
]}

Xu, Baoli ^{[1
]}

Wang, Junjun ^{[1
]}

Wang, Wenzhen ^{[2
]}

Sha, Shanshan ^{[2
]}

Sun, Yongjin ^{[1
]}

机构：

[1] Dalian Univ, Affiliated Zhongshan Hosp, Dalian 116001, Peoples R China

[2] Dalian Med Univ, Dept Biochem & Mol Biol, Dalian 116044, Peoples R China

来源：

BIOMARKERS IN MEDICINE | 2024年 / 18卷 / 17-18期

关键词：

acute ischemic stroke; biomarker; metabolite; metabolome; stroke; stroke diagnosis; MARKER; BRAIN; LEVEL; TENECTEPLASE; ASSOCIATION; DESMOSTEROL; MANAGEMENT; ALTEPLASE; GLUTAMATE; PROTEIN;

D O I：

10.1080/17520363.2024.2389033

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: To identify novel metabolic biomarkers for patients with acute ischemic stroke (AIS). Methods: The metabolites in the sera of 63 patients with AIS aged 45 similar to 77 years and 60 healthy individuals were analyzed by liquid chromatography (LC)-mass spectrometry (MS)/MS. The efficiency of significantly altered metabolites as biomarkers of AIS was evaluated by ROC curve analysis. Results: Different metabolic profiles were revealed in AIS patients' sera compared with healthy persons. Twelve significantly altered metabolites had an area under the curve (AUC) value >0.80, demonstrating their potential as a biomarker of AIS. Among them, six metabolites are firstly reported to distinguish between AIS patients and healthy individuals. Conclusion: These 12 metabolites can be further researched as potential diagnostic biomarkers of AIS.

引用

页码：727 / 737

页数：11

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