CAIDE Score, Alzheimer's Disease Pathology, and Cognition in Cognitively Normal Adults: The CABLE Study

被引:0
作者
Guo, Ze-Xin [1 ]
Liu, Fang [2 ]
Wang, Fang-Yuan [1 ]
Ou, Ya-Nan [1 ]
Huang, Liang-Yu [1 ]
Hu, Hao [1 ]
Wang, Zhi-Bo [1 ]
Fu, Yan [1 ]
Gao, Pei-Yang [1 ]
Tan, Lan [1 ]
Yu, Jin-Tai [3 ,4 ]
机构
[1] Qingdao Univ, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Peoples R China
[2] Shandong Xiehe Univ, Jinan, Shandong, Peoples R China
[3] Fudan Univ, Shanghai Med Coll, Dept Neurol, Huashan Hosp, Shanghai, Peoples R China
[4] Fudan Univ, Shanghai Med Coll, Inst Neurol, Huashan Hosp, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
Alzheimer's disease; CAIDE dementia risk score; cerebrospinal fluid biomarkers; cognition; neurodegeneration; RISK SCORE; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; APOLIPOPROTEIN E4; DEMENTIA RISK; RECOMMENDATIONS; NEURODEGENERATION; POPULATION; IMPAIRMENT;
D O I
10.3233/JAD-240005
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) risk score serves as a credible predictor of an individual's risk of dementia. However, studies on the link of the CAIDE score to Alzheimer's disease (AD) pathology are scarce. Objective: To explore the links of CAIDE score to cerebrospinal fluid (CSF) biomarkers of AD as well as to cognitive performance. Methods: In the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study, we recruited 600 cognitively normal participants. Correlations between the CAIDE score and CSF biomarkers of AD as well as cognitive performance were probed through multiple linear regression models. Whether the correlation between CAIDE score and cognitive performance was mediated by AD pathology was researched by means of mediation analyses. Results: Linear regression analyses illustrated that CAIDE score was positively associated with tau-related biomarkers, including pTau (p < 0.001), tTau (p < 0.001), as well as tTau/A beta 42 (p = 0.008), while it was in negative association with cognitive scores, consisting of MMSE score (p < 0.001) as well as MoCA score (p < 0.001). The correlation from CAIDE score to cognitive scores was in part mediated by tau pathology, with a mediation rate varying from 3.2% to 13.2%. Conclusions: A higher CAIDE score, as demonstrated in our study, was linked to more severe tau pathology and poorer cognitive performance, and tau pathology mediated the link of CAIDE score to cognitive performance. Increased dementia risk will lead to cognitive decline through aggravating neurodegeneration.
引用
收藏
页码:1273 / 1283
页数:11
相关论文
共 53 条
[1]   Changes in cognition [J].
Albert, Marilyn S. .
NEUROBIOLOGY OF AGING, 2011, 32 :S58-S63
[2]   The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].
Albert, Marilyn S. ;
DeKosky, Steven T. ;
Dickson, Dennis ;
Dubois, Bruno ;
Feldman, Howard H. ;
Fox, Nick C. ;
Gamst, Anthony ;
Holtzman, David M. ;
Jagust, William J. ;
Petersen, Ronald C. ;
Snyder, Peter J. ;
Carrillo, Maria C. ;
Thies, Bill ;
Phelps, Creighton H. .
ALZHEIMERS & DEMENTIA, 2011, 7 (03) :270-279
[3]   2023 Alzheimer's disease facts and figures [J].
不详 .
ALZHEIMERS & DEMENTIA, 2023, 19 (04) :1598-1695
[4]   A Self-Report Risk Index to Predict Occurrence of Dementia in Three Independent Cohorts of Older Adults: The ANU-ADRI [J].
Anstey, Kaarin J. ;
Cherbuin, Nicolas ;
Herath, Pushpani M. ;
Qiu, Chengxuan ;
Kuller, Lewis H. ;
Lopez, Oscar L. ;
Wilson, Robert S. ;
Fratiglioni, Laura .
PLOS ONE, 2014, 9 (01)
[5]   The Alzheimer's Disease Clinical Spectrum Diagnosis and Management [J].
Atri, Alireza .
MEDICAL CLINICS OF NORTH AMERICA, 2019, 103 (02) :263-+
[6]   A nonlinear isobologram model with Box-Cox transformation to both sides for chemical mixtures [J].
Chen, DG ;
Pounds, JG .
ENVIRONMENTAL HEALTH PERSPECTIVES, 1998, 106 :1367-1371
[7]   Validation of the Chinese Version of Montreal Cognitive Assessment Basic for Screening Mild Cognitive Impairment [J].
Chen, Ke-Liang ;
Xu, Yan ;
Chu, Ai-Qun ;
Ding, Ding ;
Liang, Xiao-Niu ;
Nasreddine, Ziad S. ;
Dong, Qiang ;
Hong, Zhen ;
Zhao, Qian-Hua ;
Guo, Qi-Hao .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2016, 64 (12) :E285-E290
[8]   Age-Related Cognitive Decline, Focus on Microbiome: A Systematic Review and Meta-Analysis [J].
Coradduzza, Donatella ;
Sedda, Stefania ;
Cruciani, Sara ;
De Miglio, Maria Rosaria ;
Ventura, Carlo ;
Nivoli, Alessandra ;
Maioli, Margherita .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (18)
[9]   Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria [J].
Dubois, Bruno ;
Hampel, Harald ;
Feldman, Howard H. ;
Scheltens, Philip ;
Aisen, Paul ;
Andrieu, Sandrine ;
Bakardjian, Hovagim ;
Benali, Habib ;
Bertram, Lars ;
Blennow, Kaj ;
Broich, Karl ;
Cavedo, Enrica ;
Crutch, Sebastian ;
Dartigues, Jean-Francois ;
Duyckaerts, Charles ;
Epelbaum, Stephane ;
Frisoni, Giovanni B. ;
Gauthier, Serge ;
Genthon, Remy ;
Gouw, Alida A. ;
Habert, Marie-Odile ;
Holtzman, David M. ;
Kivipelto, Miia ;
Lista, Simone ;
Molinuevo, Jose-Luis ;
O'Bryant, Sid E. ;
Rabinovici, Gil D. ;
Rowe, Christopher ;
Salloway, Stephen ;
Schneider, Lon S. ;
Sperling, Reisa ;
Teichmann, Marc ;
Carrillo, Maria C. ;
Cummings, Jeffrey ;
Jack, Cliff R., Jr. .
ALZHEIMERS & DEMENTIA, 2016, 12 (03) :292-323
[10]  
Ecay-Torres M, 2018, NEUROLOGY, V91, pE217, DOI [10.1212/WNL.0000000000005824, 10.1212/wnl.0000000000005824]