MSC-Based Cell Therapy in Neurological Diseases: A Concise Review of the Literature in Pre-Clinical and Clinical Research

被引：11
作者：
Zhang, Xiaorui [1 ]
Kuang, Qihong [1 ,2 ]
Xu, Jianguang [1 ]
Lin, Qing [1 ]
Chi, Haoming [1 ]
Yu, Daojin [1 ]
机构：
[1] Fujian Agr & Forestry Univ, Univ Key Lab Integrated Chinese Tradit & Western V, Fujian Key Lab Tradit Chinese Vet Med & Anim Hlth, Fuzhou 350002, Peoples R China
[2] Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Peoples R China
来源：
BIOMOLECULES | 2024年 / 14卷 / 05期
基金：
中国国家自然科学基金;
关键词：
MSCs; neurological diseases; animal studies; MESENCHYMAL STEM-CELLS; UMBILICAL-CORD BLOOD; MARROW STROMAL CELLS; PROGRESSIVE MULTIPLE-SCLEROSIS; IN-VITRO MODEL; BONE-MARROW; SPINAL-CORD; FUNCTIONAL RECOVERY; ADIPOSE-TISSUE; ANIMAL-MODELS;
D O I：
10.3390/biom14050538
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mesenchymal stem cells (MSCs) are multipotent stromal cells with the ability to self-renew and multi-directional differentiation potential. Exogenously administered MSCs can migrate to damaged tissue sites and participate in the repair of damaged tissues. A large number of pre-clinical studies and clinical trials have demonstrated that MSCs have the potential to treat the abnormalities of congenital nervous system and neurodegenerative diseases. Therefore, MSCs hold great promise in the treatment of neurological diseases. Here, we summarize and highlight current progress in the understanding of the underlying mechanisms and strategies of MSC application in neurological diseases.
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页数：18
相关论文
共 132 条
[1]   Rat Cranial Bone-Derived Mesenchymal Stem Cell Transplantation Promotes Functional Recovery in Ischemic Stroke Model Rats [J].
Abiko, Masaru ;
Mitsuhara, Takafumi ;
Okazaki, Takahito ;
Imura, Takeshi ;
Nakagawa, Kei ;
Otsuka, Takashi ;
Oshita, Jumpei ;
Takeda, Masaaki ;
Kawahara, Yumi ;
Yuge, Louis ;
Kurisu, Kaoru .
STEM CELLS AND DEVELOPMENT, 2018, 27 (15) :1053-1061
[2]  
Akiyama Y, 2002, J NEUROSCI, V22, P6623
[3]  
American Heart Association Statistics Committee Stroke Statistics Subcommittee, 2009, Circulation, V119, pe85
[4]   Effect of aging on behaviour of mesenchymal stem cells [J].
Antonio Fafian-Labora, Juan ;
Morente-Lopez, Miriam ;
Arufe, Maria C. .
WORLD JOURNAL OF STEM CELLS, 2019, 11 (06) :337-346
[5]   Notch signaling and neuronal death in stroke [J].
Arumugam, Thiruma V. ;
Baik, Sang-Ha ;
Balaganapathy, Priyanka ;
Sobey, Christopher G. ;
Mattson, Mark P. ;
Jo, Dong-Gyu .
PROGRESS IN NEUROBIOLOGY, 2018, 165 :103-116
[6]   Time-Dependent Migration of Systemically Delivered Bone Marrow Mesenchymal Stem Cells to the Infarcted Heart [J].
Assis, Ana Carolina M. ;
Carvalho, Juliana L. ;
Jacoby, Bruno A. ;
Ferreira, Raphael L. B. ;
Castanheira, Paula ;
Diniz, Simone O. F. ;
Cardoso, Valbert N. ;
Goes, Alfredo M. ;
Ferreira, Anderson J. .
CELL TRANSPLANTATION, 2010, 19 (02) :219-230
[7]   Transplanted Bone Marrow Mesenchymal Stem Cells Improve Memory in Rat Models of Alzheimer's Disease [J].
Babaei, Parvin ;
Tehrani, Bahram Soltani ;
Alizadeh, Arsalan .
STEM CELLS INTERNATIONAL, 2012, 2012
[8]   Hepatocyte growth factor mediates mesenchymal stem cell-induced recovery in multiple sclerosis models [J].
Bai, Lianhua ;
Lennon, Donald P. ;
Caplan, Arnold I. ;
DeChant, Anne ;
Hecker, Jordan ;
Kranso, Janet ;
Zaremba, Anita ;
Miller, Robert H. .
NATURE NEUROSCIENCE, 2012, 15 (06) :862-U86
[9]   Increased Migration of Human Mesenchymal Stromal Cells by Autocrine Motility Factor (AMF) Resulted in Enhanced Recruitment towards Hepatocellular Carcinoma [J].
Bayo, Juan ;
Fiore, Esteban ;
Aquino, Jorge B. ;
Malvicini, Mariana ;
Rizzo, Manglio ;
Peixoto, Estanislao ;
Andriani, Oscar ;
Alaniz, Laura ;
Piccioni, Flavia ;
Bolontrade, Marcela ;
Podhajcer, Osvaldo ;
Garcia, Mariana G. ;
Mazzolini, Guillermo .
PLOS ONE, 2014, 9 (04)
[10]   Loneliness in women with multiple sclerosis [J].
Beal, Claudia C. ;
Stuifbergen, Alexa .
REHABILITATION NURSING, 2007, 32 (04) :165-171
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