Exploring membrane damage mechanisms of heterogeneous tau and amylin oligomers in Alzheimer's using MD simulations

被引：0
|
作者：
Cheng, Kwan Hon K. [1 ,2 ]
Santos, Natalia [2 ]
Segura, Luthary [2 ]
机构：
[1] Trinity Univ, Dept Phys, San Antonio, TX USA
[2] Trinity Univ, Dept Neurosci, San Antonio, TX USA
来源：
BIOPHYSICAL JOURNAL | 2024年 / 123卷 / 03期
关键词：
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
2736-Pos
引用
收藏
页码：490A / 490A
页数：1
相关论文
共 16 条
  • [1] Molecular Mechanisms of Protein-Lipid Interactions and Protein Folding of Heterogeneous Amylin and Tau Oligomers on Lipid Nanodomains That Link to Alzheimer's
    Santos, Natalia
    Segura, Luthary
    Lewis, Amber
    Pham, Thuong
    Cheng, Kwan H.
    MACROMOL, 2023, 3 (04): : 805 - 827
  • [2] Exploring membrane binding targets of tau oligomers on phase-separated lipid bilayers using multiscale MD simulations
    Cheng, Kwan Hon K.
    Graf, Angela
    Lewis, Amber
    Pham, Thuong L.
    Aacharya, Aakriti
    BIOPHYSICAL JOURNAL, 2023, 122 (03) : 502A - 503A
  • [3] Heterogeneous Tau Oligomers as Molecular Targets for Alzheimer's Disease and Related Tauopathies
    Lo, Chih Hung
    BIOPHYSICA, 2022, 2 (04): : 440 - 451
  • [4] Revisiting lipid II binding by teixobactin oligomers using membrane MD simulations
    Wen, Po-Chao
    Rempe, Susan L.
    Tajkhorshid, Emad
    BIOPHYSICAL JOURNAL, 2022, 121 (03) : 161A - 161A
  • [5] Amylin-Aβ oligomers at atomic resolution using molecular dynamics simulations: a link between Type 2 diabetes and Alzheimer's disease
    Baram, Michal
    Atsmon-Raz, Yoav
    Ma, Buyong
    Nussinov, Ruth
    Miller, Yifat
    PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2016, 18 (04) : 2330 - 2338
  • [6] Molecular dynamics simulations to investigate protein folding of cross-seeded tau and amylin in Alzheimer's disease
    Santos, Natalia
    Segura, Luthary
    Cheng, Kwan Hon K.
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 213A - 213A
  • [7] Multiscale Modeling of Macromolecular Interactions between Tau-Amylin Oligomers and Asymmetric Lipid Nanodomains That Link Alzheimer's and Diabetic Diseases
    Santos, Natalia
    Segura, Luthary
    Lewis, Amber
    Pham, Thuong
    Cheng, Kwan H.
    MOLECULES, 2024, 29 (03):
  • [8] Insights into Alzheimer's Disease: Molecular Dynamics (MD) Simulations of Peptide-Membrane Interactions
    Brown, Anne
    Polys, Nicholas
    Bevan, David
    Mohammed, Ayat
    PROCEEDINGS OF XSEDE16: DIVERSITY, BIG DATA, AND SCIENCE AT SCALE, 2016,
  • [9] Exploring Membrane Binding Targets of Disordered Human Tau Aggregates on Lipid Rafts Using Multiscale Molecular Dynamics Simulations
    Cheng, Kwan H.
    Graf, Angela
    Lewis, Amber
    Thuong Pham
    Acharya, Aakriti
    MEMBRANES, 2022, 12 (11)
  • [10] Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies
    Puangmalai, Nicha
    Bhatt, Nemil
    Montalbano, Mauro
    Sengupta, Urmi
    Gaikwad, Sagar
    Ventura, Frank
    McAllen, Salome
    Ellsworth, Anna
    Garcia, Stephanie
    Kayed, Rakez
    CELL DEATH & DISEASE, 2020, 11 (05)
12