Dyslipidemia and ANGPTL8 evaluation in young females with Type 1 diabetes mellitus

被引:3
作者
Mohammedsaeed, Walaa [1 ]
Binjawhar, Dalal [2 ]
机构
[1] Taibah Univ, Dept Clin Lab Sci, Fac Appl Med Sci, Madinah, Saudi Arabia
[2] Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Chem, Riyadh, Saudi Arabia
关键词
ANGPTL8; Lipid profile; Glucose; Insulin; Type; 1; diabetes; PANCREATIC BETA-CELL; INCREASED CIRCULATING LEVELS; ANGIOPOIETIN-LIKE PROTEIN; BETATROPHIN CONCENTRATIONS; LIPID PROFILES; ADOLESCENTS; PREVALENCE; CHILDREN; GLUCOSE; YOUTH;
D O I
10.1007/s12020-024-03909-x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
PurposeANGPTL8, commonly referred to as betatrophin, has demonstrated promise as a dependable marker for the onset of complications associated with diabetes mellitus, such as dyslipidemia. The objective of this study is to evaluate the lipid profile and ANGPTL8 levels in people diagnosed with Type 1 Diabetes Mellitus (T1DM).MethodsA retrospective case-control study was performed on a group of 100 adolescent females, aged 13-17 years. This group consisted of individuals diagnosed with T1DM from the Diabetes and Endocrine Department at Medina's King Fahad Hospital in Saudi Arabia. Additionally, 100 healthy adolescent females of the same age range were included as controls. The hospital conducted laboratory studies to evaluate glucose, HbA1c, insulin, and lipid profiles. The ANGPTL8 levels were quantified using Enzyme-Linked Immunosorbent Assay (ELISA).ResultsPatients with T1DM had ANGPTL8 levels that were twice as high as those observed in individuals without any health conditions. The two groups had contrasting levels of fasting blood glucose (FBG), glycated hemoglobin (HbA1c), C-peptides, triacylglycerol (TG), and cholesterol, along with elevated Atherogenic Index of Plasma readings. Diabetes mellitus patients had considerably elevated values compared to the control group. There was a significant correlation between ANGPTL8 concentrations and lipid abnormalities, with P-values less than 0.05. 56% of the 100 patients exhibited dyslipidemia. The research found a correlation between dyslipidemia and elevated levels of ANGPTL8 in diabetic patients. The concentration of ANGPTL8 had a positive correlation with glucose, HbA1c, TG, and C-peptides while displaying a negative correlation with high-density lipoprotein cholesterol (HDL-C).ConclusionANGPTL8 levels were found to be elevated in Saudi young women who were diagnosed with TIDM. ANGPTL8 may potentially contribute to dyslipidemia in individuals with T1DM, hence increasing the susceptibility to cardiovascular disease (CVD). Therefore, ANGPTL8 has the potential to impact lipid metabolism, namely Triglycerides, as a biological route. The results highlight the need to analyze lipid profiles and do ANGPTL8 testing in young females diagnosed with T1DM at an early stage to prevent complications.
引用
收藏
页码:564 / 573
页数:10
相关论文
共 56 条
[11]   Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].
Cleeman, JI ;
Grundy, SM ;
Becker, D ;
Clark, LT ;
Cooper, RS ;
Denke, MA ;
Howard, WJ ;
Hunninghake, DB ;
Illingworth, DR ;
Luepker, RV ;
McBride, P ;
McKenney, JM ;
Pasternak, RC ;
Stone, NJ ;
Van Horn, L ;
Brewer, HB ;
Ernst, ND ;
Gordon, D ;
Levy, D ;
Rifkind, B ;
Rossouw, JE ;
Savage, P ;
Haffner, SM ;
Orloff, DG ;
Proschan, MA ;
Schwartz, JS ;
Sempos, CT ;
Shero, ST ;
Murray, EZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497
[12]   Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease [J].
Dewey, F. E. ;
Gusarova, V. ;
Dunbar, R. L. ;
O'Dushlaine, C. ;
Schurmann, C. ;
Gottesman, O. ;
McCarthy, S. ;
Van Hout, C. V. ;
Bruse, S. ;
Dansky, H. M. ;
Leader, J. B. ;
Murray, M. F. ;
Ritchie, M. D. ;
Kirchner, H. L. ;
Habegger, L. ;
Lopez, A. ;
Penn, J. ;
Zhao, A. ;
Shao, W. ;
Stahl, N. ;
Murphy, A. J. ;
Hamon, S. ;
Bouzelmat, A. ;
Zhang, R. ;
Shumel, B. ;
Pordy, R. ;
Gipe, D. ;
Herman, G. A. ;
Sheu, W. H. H. ;
Lee, I-T. ;
Liang, K. -W. ;
Guo, X. ;
Rotter, J. I. ;
Chen, Y. -D. I. ;
Kraus, W. E. ;
Shah, S. H. ;
Damrauer, S. ;
Small, A. ;
Rader, D. J. ;
Wulff, A. B. ;
Nordestgaard, B. G. ;
Tybjaerg-Hansen, A. ;
van den Hoek, A. M. ;
Princen, H. M. G. ;
Ledbetter, D. H. ;
Carey, D. J. ;
Overton, J. D. ;
Reid, J. G. ;
Sasiela, W. J. ;
Banerjee, P. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (03) :211-221
[13]   Longitudinal screening of serum lipids in children and adolescents with Type 1 diabetes in a UK clinic population [J].
Edge, J. A. ;
James, T. ;
Shine, B. .
DIABETIC MEDICINE, 2008, 25 (08) :942-948
[14]  
Enteshary M., 2019, Asian Journal of Sports Medicine, V10, DOI [10.5812/asjsm.68943, DOI 10.5812/ASJSM.68943]
[15]   Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes [J].
Espes, Daniel ;
Martinell, Mats ;
Carlsson, Per-Ola .
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2014, 2014
[16]   Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes [J].
Espes, Daniel ;
Lau, Joey ;
Carlsson, Per-Ola .
DIABETOLOGIA, 2014, 57 (01) :50-53
[17]   Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals [J].
Fenzl, Anna ;
Itariu, Bianca K. ;
Kosi, Lana ;
Fritzer-Szekeres, Monika ;
Kautzky-Willer, Alexandra ;
Stulnig, Thomas M. ;
Kiefer, Florian W. .
DIABETOLOGIA, 2014, 57 (06) :1204-1208
[18]   Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity [J].
Fu, Zhiyao ;
Berhane, Feven ;
Fite, Alemu ;
Seyoum, Berhane ;
Abou-Samra, Abdul B. ;
Zhang, Ren .
SCIENTIFIC REPORTS, 2014, 4
[19]   Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family [J].
Fu, Zhiyao ;
Yao, Fayi ;
Abou-Samra, Abdul B. ;
Zhang, Ren .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 430 (03) :1126-1131
[20]   Circulating Betatrophin Concentrations Are Decreased in Human Obesity and Type 2 Diabetes [J].
Gomez-Ambrosi, Javier ;
Pascual, Eider ;
Catalan, Victoria ;
Rodriguez, Amaia ;
Ramirez, Beatriz ;
Silva, Camilo ;
Gil, Mara J. ;
Salvador, Javier ;
Fruehbeck, Gema .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (10) :E2004-E2009