The therapeutic potential of typical plant-derived compounds for the management of metabolic disorders

被引:4
作者
Roy, Debajyoti [1 ,2 ]
Kaur, Prabhjot [3 ]
Ghosh, Maitrayee [2 ]
Choudhary, Deepika [4 ]
Rangra, Naresh Kumar [5 ]
机构
[1] ISF Coll Pharm, Dept Pharmacognosy, Moga, Punjab, India
[2] CV Raman Global Univ, Dept Pharm, Bhubaneswar, Odisha, India
[3] ISF Coll Pharm, Dept Pharmaceut Chem, Moga, Punjab, India
[4] Cent Univ Punjab, Dept Pharmaceut Sci & Nat Prod, Bathinda, Punjab, India
[5] Chitkara Univ, Chitkara Sch Pharm, Baddi 174103, Himachal Prades, India
关键词
berberine; curcumin; obesity; quercetin; resveratrol; Type; 2; diabetes; ACTIVATED PROTEIN-KINASE; GREEN TEA; RESVERATROL SUPPLEMENTATION; EPIGALLOCATECHIN GALLATE; INSULIN-RESISTANCE; HEPATIC STEATOSIS; NANO-CURCUMIN; OBESE MICE; COMPLEX-I; BERBERINE;
D O I
10.1002/ptr.8238
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Obesity and Type 2 diabetes are prevalent metabolic dysfunctions that present significant health challenges worldwide. Available cures for these ailments have constraints with accompanying unwanted effects that persistently exist. Compounds originated from plants have recently been introduced as hopeful remedies to treat metabolic disorders because of their diverse pharmacological activities. This detailed observation gives an introduction into the treatment capacity of plant-derived compounds regarding metabolic syndromes while analyzing various groups alongside their performance in this field despite unique mechanisms designed by nature itself. Interestingly, this study provides some examples including curcumin, resveratrol, quercetin, berberine, epigallocatechin gallate (EGCG), and capsaicin, which highlights potential therapeutic impacts for future testing. However, current clinical trials inspecting human studies investigating efficacies concerning metabolism challenge present limitations. Finally, the review weighs up bad reactions possibly inflicted after administering plant-originated materials though suggestive insights will be provided later. Above all, it outlines the chance to identify novel therapies encapsulated within natural substances based upon recent developments could hold significant promise toward managing misplaced metabolisms globally. Therapeutic Potential of Plant-Derived Compounds in Managing Metabolic Disorders. image
引用
收藏
页码:3986 / 4008
页数:23
相关论文
共 126 条
[1]   Ameliorative effect of curcumin and zinc oxide nanoparticles on multiple mechanisms in obese rats with induced type 2 diabetes [J].
Abdulmalek, Shaymaa ;
Eldala, Asmaa ;
Awad, Doaa ;
Balbaa, Mahmoud .
SCIENTIFIC REPORTS, 2021, 11 (01)
[2]   The effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials [J].
Akbari, Maryam ;
Tamtaji, Omid Reza ;
Lankarani, Kamran B. ;
Tabrizi, Reza ;
Dadgostar, Ehsan ;
Haghighat, Neda ;
Kolahdooz, Fariba ;
Ghaderi, Amir ;
Mansournia, Mohammad Ali ;
Asemi, Zatollah .
LIPIDS IN HEALTH AND DISEASE, 2020, 19 (01)
[3]  
Ali A. T., 2014, BIOMED RES INT, V2014, P229, DOI [10.1016/j.ejcb.2013.06.001, DOI 10.1016/J.EJCB.2013.06.001]
[4]  
American Association for Clinical Chemistry, 2022, METABOLIC DISORDERS
[5]  
American Heart association, 2021, About Metabolic Syndrome
[6]  
[Anonymous], NUTR METABOLISM DISO
[7]   A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health [J].
Banez, Melissa J. ;
Geluz, Matthew, I ;
Chandra, Anjali ;
Hamdan, Tesnim ;
Biswas, Olivia S. ;
Bryan, Nathan S. ;
Von Schwarz, Ernst R. .
NUTRITION RESEARCH, 2020, 78 :11-26
[8]   Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment [J].
Basnet, Purusotam ;
Skalko-Basnet, Natasa .
MOLECULES, 2011, 16 (06) :4567-4598
[9]   Therapeutic potential of resveratrol:: the in vivo evidence [J].
Baur, Joseph A. ;
Sinclair, David A. .
NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (06) :493-506
[10]   Ameliorative effects of quercetin on the preimplantation embryos development in diabetic pregnant mice [J].
Bolouki, Ayeh ;
Zal, Fatemeh ;
Alaee, Sanaz .
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2020, 46 (05) :736-744