Association between obstructive sleep apnea severity and depression risk: a systematic review and dose-response meta-analysis

被引:5
作者
Zhao, Dong-Fang [1 ]
Zhang, Yi-Zhu [2 ]
Sun, Xue [1 ]
Su, Chun-Yan [3 ]
Zhang, Li-Qiang [4 ]
机构
[1] Peking Univ Third Hosp, Dept Resp & Crit Care Med, Beijing, Peoples R China
[2] Peking Univ, Sch Nursing, Beijing, Peoples R China
[3] Peking Univ Third Hosp, Dept Nephrol, 49 Huayuanbei Rd, Beijing 100191, Peoples R China
[4] Peking Univ Third Hosp, Sleep Med Ctr, Dept Resp & Crit Care Med, 49 Huayuanbei Rd, Beijing 100191, Peoples R China
关键词
Obstructive sleep apnea; Depression; Depressive symptoms; Dose-response meta-analysis; POSITIVE AIRWAY PRESSURE;
D O I
10.1007/s11325-024-03083-4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Obstructive sleep apnea (OSA) has received considerable attention as a potential risk factor for depressive symptoms. The systematic review was conducted to confirm the dose-response connection between OSA severity and depression risk. A systematic literature search of English and Chinese articles published in PubMed, EMBASE, Scopus, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and SinoMed databases from their inception to 28 August 2023 was conducted. An evaluation using the Newcastle-Ottawa Scale was performed. A meta-analysis was used to evaluate the impact of OSA severity. A random-effects dose-response model was conducted to evaluate the linear and nonlinear dose-response connections. We evaluated publication bias by funnel plots, and symmetry by Egger's test. We identified 18 cross-sectional researches. 3143 participants which were involved in the dose-response meta-analysis. Contrasted with mild OSA, individuals with severe OSA had a higher adjusted risk of depression (rate ratio: 1.34, 95% confidence interval = 1.05-1.70), with substantial heterogeneity (I-2 = 70.9%, P(heterogeneity<)0.001). There is a significant linear connection between OSA severity and depression risk. The depression risk increased by 0.4% for every 1 event per hour increase in the apnea-hypopnea index (AHI). The protocol for this unfunded research was drafted and registered at PROSPERO (ID CRD42023474097).
引用
收藏
页码:2175 / 2185
页数:11
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